Publications

Müller JA, Betzin J, Santos-Tejedor J, Mayer A, Oprişoreanu A-M, Engholm-Keller K, Paulußen I, Gulakova P, McGovern TD, Gschossman LJ, Schönhense E, Wark JR, Lamprecht A, Becker AJ, Waardenberg AJ, Graham ME, Dietrich D, Schoch S (2022) A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Cell Reports 39:110696. https://doi.org/10.1016/j.celrep.2022.110696


Tsortouktzidis D, Tröscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, Loo KMJ van (2022) A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological CaV3.2 Channelopathies by Promoter-Mediated Transcription Control. Front Mol Neurosci 14:667143. https://doi.org/10.3389/fnmol.2021.667143


Hilton BJ, Husch A, Schaffran B, Lin T, Burnside ER, Dupraz S, Schelski M, Kim J, Müller JA, Schoch S, Imig C, Brose N, Bradke F (2022) An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury. Neuron 110:51-69.e7. https://doi.org/10.1016/j.neuron.2021.10.007


Cases-Cunillera S, Loo KMJ van, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, Borger V, Dietrich D, Schoch S, Becker AJ (2022) Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss. Neuro-oncology 24:741–754. https://doi.org/10.1093/neuonc/noab268


Matthews EA, Sun W, McMahon SM, Doengi M, Halka L, Anders S, Müller JA, Steinlein P, Vana NS, Dyk G van, Pitsch J, Becker AJ, Pfeifer A, Kavalali ET, Lamprecht A, Henneberger C, Stein V, Schoch S*, Dietrich D (2022) Optical Analysis of Glutamate Spread in the Neuropil. Cereb Cortex bhab440-. https://doi.org/10.1093/cercor/bhab440, *co-corresponding author


Ganainy SOE, Cijsouw T, Ali MA, Schoch S, Hanafy AS (2022) Stereotaxic-assisted gene therapy in Alzheimer’s and Parkinson’s diseases: therapeutic potentials and clinical frontiers. Expert Rev Neurother 22:319–335. https://doi.org/10.1080/14737175.2022.2056446


Lichter K, Paul MM, Pauli M, Schoch S, Kollmannsberger P, Stigloher C, Heckmann M, Sirén A-L (2022) Ultrastructural analysis of wildtype and RIM1α knock-out active zones in a large cortical synapse. Biorxiv 2022.03.04.482996. https://doi.org/10.1101/2022.03.04.482996


Reimers A, Hummel CA, Eis-Hübinger AM, Surges R, Niehusmann P, Schoch S, Becker AJ, Pitsch J (2021) Analysis of autoantibody spectrum and human herpesvirus 6 in adult patients with ‘early’ versus ‘late’ diagnosis of ‘possible limbic encephalitis.’ Epilepsy Res 176:106698. https://doi.org/10.1016/j.eplepsyres.2021.106698


Pitsch J, Loo KMJ, Gallus M, Dik A, Kamalizade D, Baumgart A, Gnatkovsky V, Müller JA, Opitz T, Hicking G, Naik VN, Wachsmuth L, Faber C, Surges R, Kurts C, Schoch S, Melzer N, Becker AJ (2021) CD8 + T‐Lymphocyte–Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy. Ann Neurol 89:666–685. https://doi.org/10.1002/ana.26000


Hochfeld LM, Bertolini M, Broadley D, Botchkareva NV, Betz RC, Schoch S, Nöthen MM, Heilmann-Heimbach S (2021) Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness. Plos One 16:e0256846. https://doi.org/10.1371/journal.pone.0256846


Minge D, Domingos C, Unichenko P, Behringer C, Pauletti A, Anders S, Herde MK, Delekate A, Gulakova P, Schoch S, Petzold GC, Henneberger C (2021) Heterogeneity and Development of Fine Astrocyte Morphology Captured by Diffraction-Limited Microscopy. Front Cell Neurosci 15:669280. https://doi.org/10.3389/fncel.2021.669280


Wrede R von, Jeub M, Ariöz I, Elger CE, Voss H von, Klein H-G, Becker AJ, Schoch S, Surges R, Kunz WS (2021) Novel KCNH1 Mutations Associated with Epilepsy: Broadening the Phenotypic Spectrum of KCNH1-Associated Diseases. Genes-basel 12:132. https://doi.org/10.3390/genes12020132


Stevelink R, Luykx JJ, Lin BD, Leu C, Lal D, Smith AW, Schijven D, Carpay JA, Rademaker K, Baldez RAR, Devinsky O, Braun KPJ, Jansen FE, Smit DJA, Koeleman BPC, Abou‐Khalil B, Auce P, Avbersek A, Bahlo M, Balding DJ, Bast T, Baum L, Becker AJ, Becker F, Berghuis B, Berkovic SF, Boysen KE, Bradfield JP, Brody LC, Buono RJ, Campbell E, Cascino GD, Catarino CB, Cavalleri GL, Cherny SS, Chinthapalli K, Coffey AJ, Compston A, Coppola A, Cossette P, Craig JJ, Haan G de, Jonghe PD, Kovel CGF de, Delanty N, Depondt C, Dlugos DJ, Doherty CP, Elger CE, Eriksson JG, Ferraro TN, Feucht M, Francis B, Franke A, French JA, Freytag S, Gaus V, Geller EB, Gieger C, Glauser T, Glynn S, Goldstein DB, Gui H, Guo Y, Haas KF, Hakonarson H, Hallmann K, Haut S, Heinzen EL, Helbig I, Hengsbach C, Hjalgrim H, Iacomino M, Ingason A, Jamnadas‐Khoda J, Johnson MR, Kälviäinen R, Kantanen A, Kasperavičiūte D, Trenite DK, Kirsch HE, Knowlton RC, Krause R, Krenn M, Kunz WS, Kuzniecky R, Kwan P, Lau Y, Lehesjoki A, Lerche H, Lieb W, Lindhout D, Lo WD, Lopes‐Cendes I, Lowenstein DH, Malovini A, Marson AG, Mayer T, McCormack M, Mills JL, Mirza N, Moerzinger M, Møller RS, Molloy AM, Muhle H, Newton M, Ng P, Nöthen MM, Nürnberg P, O’Brien TJ, Oliver KL, Palotie A, Pangilinan F, Peter S, Petrovski S, Poduri A, Privitera M, Radtke R, Rau S, Reif PS, Reinthaler EM, Rosenow F, Sander JW, Sander T, Scattergood T, Schachter SC, Schankin CJ, Scheffer IE, Schmitz B, Schoch S, Sham PC, Shih JJ, Sills GJ, Sisodiya SM, Slattery L, Smith DF, Smith MC, Smith PE, Sonsma ACM, Speed D, Sperling MR, Steinhoff BJ, Stephani U, Strauch K, Striano P, Stroink H, Surges R, Tan KM, Thio LL, Thomas GN, Todaro M, Tozzi R, Vari MS, Vining EPG, Visscher F, Spiczak S von, Walley NM, Weber YG, Wei Z, Mameniskiene R, Weisenberg J, Whelan CD, Widdess‐Walsh P, Wolff M, Wolking S, Yang W, Zara F, Zimprich F, Feng YA, Howrigan DP, Abbott LE, Tashman K, Cerrato F, Lal D, Churchhouse C, Gupta N, Gabriel SB, Daly MJ, Lander ES, Neale BM, Berkovic SF, Lerche H, Goldstein DB, Lowenstein DH, Cavalleri GL, Cossette P, Cotsapas C, Jonghe PD, Dixon‐Salazar T, Guerrini R, Hakonarson H, Heinzen EL, Helbig I, Kwan P, Petrovski S, Kamalakaran S, Sisodiya SM, Stewart R, Weckhuysen S, Dlugos DJ, Scheffer IE, Striano P, Freyer C, Krause R, May P, McKenna K, Regan BM, Bellows ST, Bennett CA, Johns EMC, Macdonald A, Shilling H, Burgess R, Weckhuysen D, Bahlo M, O’Brien TJ, Todaro M, Stamberger H, Depondt C, Andrade DM, Sadoway TR, Mo K, Krestel H, Gallati S, Papacostas SS, Kousiappa I, Tanteles GA, Štěrbová K, Vlčková M, Sedláčková L, Laššuthová P, Klein KM, Rosenow F, Reif PS, Knake S, Kunz WS, Zsurka G, Elger CE, Bauer J, Rademacher M, Pendziwiat M, Muhle H, Rademacher A, Baalen A van, Spiczak S von, Stephani U, Afawi Z, Korczyn AD, Kanaan M, Canavati C, Kurlemann G, Müller‐Schlüter K, Kluger G, Häusler M, Blatt I, Lemke JR, Krey I, Weber YG, Wolking S, Becker F, Hengsbach C, Rau S, Maisch AF, Steinhoff BJ, Schulze‐Bonhage A, Schubert‐Bast S, Schreiber H, Borggräfe I, Schankin CJ, Mayer T, Korinthenberg R, Brockmann K, Dennig D, Madeleyn R, Kälviäinen R, Auvinen P, Saarela A, Linnankivi T, Lehesjoki A, Rees MI, Chung S, Pickrell WO, Powell R, Schneider N, Balestrini S, Zagaglia S, Braatz V, Marson AG, Johnson MR, Auce P, Sills GJ, Baum LW, Sham PC, Cherny SS, Lui CHT, Barišić N, Delanty N, Doherty CP, Shukralla A, McCormack M, El‐Naggar H, Canafoglia L, Franceschetti S, Castellotti B, Granata T, Zara F, Iacomino M, Madia F, Vari MS, Mancardi MM, Salpietro V, Bisulli F, Tinuper P, Licchetta L, Pippucci T, Stipa C, Minardi R, Gambardella A, Labate A, Annesi G, Manna L, Gagliardi M, Parrini E, Mei D, Vetro A, Bianchini C, Montomoli M, Doccini V, Marini C, Suzuki T, Inoue Y, Yamakawa K, Tumiene B, Sadleir LG, King C, Mountier E, Caglayan SH, Arslan M, Yapıcı Z, Yis U, Topaloglu P, Kara B, Turkdogan D, Gundogdu‐Eken A, Bebek N, Uğur‐İşeri S, Baykan B, Salman B, Haryanyan G, Yücesan E, Kesim Y, Özkara Ç, Poduri A, Buono RJ, Ferraro TN, Sperling MR, Lo W, Privitera M, French JA, Schachter S, Kuzniecky RI, Hegde M, Khankhanian P, Helbig KL, Ellis CA (2021) Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia 62:1518–1527. https://doi.org/10.1111/epi.16922


Schoch S*, Quatraccioni A, Robens BK, Maresch R, Loo KMJ van, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ (2021) Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. J Neurosci Official J Soc Neurosci 41:8111–8125. https://doi.org/10.1523/jneurosci.0352-21.2021, *co-corresponding author


Mirza N, Stevelink R, Taweel B, Koeleman BPC, Marson AG, Epilepsies ILAEC on C, Abou-Khalil B, Auce P, Avbersek A, Bahlo M, Balding DJ, Bast T, Baum L, Becker AJ, Berghuis FBB, Berkovic SF, Boysen KE, Bradfield JP, Brody LC, Buono RJ, Campbell E, Cascino GD, Catarino CB, Cavalleri GL, Cherny SS, Chinthapalli K, Coffey AJ, Compston A, Coppola A, Cossette P, Craig JJ, Haan G-J de, Jonghe PD, Kovel CGF de, Delanty N, Depondt C, Devinsky O, Dlugos DJ, Doherty CP, Elger CE, Eriksson JG, Ferraro TN, Feucht M, Francis B, Franke A, French JA, Freytag S, Gaus V, Geller EB, Gieger C, Glauser T, Glynn S, Goldstein DB, Gui H, Guo Y, Haas KF, Hakonarson H, Hallmann K, Haut S, Heinzen EL, Helbig I, Hengsbach C, Hjalgrim H, Iacomino M, Ingason A, Jamnadas-Khoda J, Johnson MR, Kälviäinen R, Kantanen A-M, Kasperavičiūte D, Trenite DK-N, Kirsch HE, Knowlton RC, Koeleman BPC, Krause R, Krenn M, Kunz WS, Kuzniecky R, Kwan P, Lal D, Lau Y-L, Lerche H, Leu C, Lieb W, Lindhout D, Lo WD, Lopes-Cendes I, Lowenstein DH, Malovini A, Marson AG, Mayer T, McCormack M, Mills JL, Mirza N, Moerzinger M, Møller RS, Molloy AM, Muhle H, Newton M, Ng P-W, Nöthen MM, Nürnberg P, O’Brien TJ, Oliver KL, Palotie A, Pangilinan F, Peter S, Petrovski S, Poduri A, Privitera M, Radtke R, Rau S, Reif PS, Reinthaler EM, Rosenow F, Sander JW, Sander T, Scattergood T, Schachter SC, Schankin CJ, Scheffer IE, Schmitz B, Schoch S, Sham PC, Shih JJ, Sills GJ, Sisodiya SM, Slattery L, Smith A, Smith DF, Smith MC, Smith PE, Sonsma ACM, Speed D, Sperling MR, Steinhoff BJ, Stephani U, Stevelink R, Strauch K, Striano P, Stroink H, Surges R, Tan KM, Thio LL, Thomas GN, Todaro M, Tozzi R, Vari MS, Vining EPG, Visscher F, Spiczak S von, Walley NM, Weber YG, Wei Z, Weisenberg J, Whelan CD, Widdess-Walsh P, Wolff M, Wolking S, Yang W, Zara F, Zimprich F (2021) Using common genetic variants to find drugs for common epilepsies. Brain Commun 3:fcab287. https://doi.org/10.1093/braincomms/fcab287


Kuehn JC, Meschede C, Helmstaedter C, Surges R, Wrede R von, Hattingen E, Vatter H, Elger CE, Schoch S, Becker AJ, Pitsch J (2020) Adult-onset temporal lobe epilepsy suspicious for autoimmune pathogenesis: Autoantibody prevalence and clinical correlates. Plos One 15:e0241289. https://doi.org/10.1371/journal.pone.0241289


Hanafy AS, Schoch S, Lamprecht A (2020) CRISPR/Cas9 Delivery Potentials in Alzheimer’s Disease Management: A Mini Review. Pharm 12:801. https://doi.org/10.3390/pharmaceutics12090801


Pitsch J, Kamalizade D, Braun A, Kuehn JC, Gulakova PE, Rüber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R, Elger CE, Hattingen E, Vatter H, Schoch S, Becker AJ. Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis. Ann Neurol. 2020 Jun;87(6):869-884


Tsortouktzidis D, Schulz H, Hamed M, Vatter H, Surges R, Schoch S, Sander T, Becker AJ, Loo KMJ van (2020) Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness. Epilepsia. https://doi.org/10.1111/epi.16789


Poll S, Mittag M, Musacchio F, Justus LC, Giovannetti EA, Steffen J, Wagner J, Zohren L, Schoch S, Schmidt B, Jackson WS, Ehninger D, Fuhrmann M. Memory trace interference impairs recall in a mouse model of Alzheimer’s disease. Nat Neurosci. 2020 Jun 8. doi: 10.1038/s41593-020-0652-4


Debski KJ, Ceglia N, Ghestem A, Ivanov AI, Brancati GE, Bröer S, Bot AM, Müller JA, Schoch S, Becker A, Löscher W, Guye M, Sassone-Corsi P, Lukasiuk K, Baldi P, Bernard C (2020) The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy. Sci Adv 6:eaat5979. https://doi.org/10.1126/sciadv.aat5979


Das R, Schwintzer L, Vinopal S, Aguado Roca E, Sylvester M, Oprisoreanu AM, Schoch S, Bradke F, Broemer M. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. J Cell Sci. 2019 Jun 17;132(12):jcs229252. doi: 10.1242/jcs.229252


Engholm-Keller K, Waardenberg AJ, Müller JA, Wark JR, Fernando RN, Arthur JW, Robinson PJ, Dietrich D, Schoch S, Graham ME. The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation. PloS Biol.; 2019 Mar. 1;17(3):e3000170


van Loo KMJ, Rummel CK, Pitscht J, Müller JA, Bikbaev AF, Martinez-Chavez E, Bleass S, Dietrich D, Heine M, Becker AJ, Schoch S. Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. J. Neurosci.; 2019 Apr. 24, 39(17);:3175-3187


Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JA, Schoch S, Quiroz FJU, Rebola N, Bao H, Little JP, Tkachuk AN, Cai E, Hantman AW, Wang SSH, DePiero VJ, Boghuis BG, Chapman ER, Dietrich D, DiGregorio DA, Fitzpatrick D, Looger LL. Stability, Affinity, and Chromatic Variants of the Glutamate Sensor iGluSnFR. Nat. Met. Springer US; 2018 Oct. 30, 15;:936–939.


Zhang WH, Herde MK, Mitchell JA, Whitfield JH, Wulff AB, Vongsouthi V, Sanchez-Romero I, Gulakova PE, Minge D, Breithausen BXR, Schoch S, Janovjak H, Jackson CJ, Henneberger C. Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS. Nat. Chem. Biol. Springer US; 2018 Jul 16;:1–13.


Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze J-F, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, et al. Analysis of shared heritability in common disorders of the brain. Science. American Association for the Advancement of Science; 2018 Jun 22;360(6395):eaap8757.


Pitsch J, Kuehn JC, Gnatkovsky V, Müller JA, van Loo KMJ, de Curtis M, Vatter H, Schoch S, Elger CE, Becker AJ. Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. Mol Neurobiol. Springer US; 2018 Jun 22;:1–16.


Kovačević J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse LN, Sullivan PF, Schoch S, Toonen RF, Stiedl O, Verhage M. Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy. Brain. 2018 Mar 12;57:15.


Schulz H, Ruppert A-K, Herms S, Wolf C, Mirza-Schreiber N, Stegle O, Czamara D, Forstner AJ, Sivalingam S, Schoch S, Moebus S, Pütz B, Hillmer A, Fricker N, Vatter H, Müller-Myhsok B, Nöthen MM, Becker AJ, Hoffmann P, Sander T, Cichon S. Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nature Communications; 2017 Nov 15;8(1):1511.


Reuter M, Montag C, Altmann S, Bendlow F, Elger C, Kirsch P, Becker A, Schoch-McGovern S, Simon M, Weber B, Felten A. Functional characterization of an oxytocin receptor gene variant (rs2268498) previously associated with social cognition by expression analysis in vitro and in human brain biopsy. Soc Neurosci. Routledge; 2017 Oct;12(5):604–11.


Löhner M, Babai N, Müller T, Gierke K, Atorf J, Joachimsthaler A, Peukert A, Martens H, Feigenspan A, Kremers J, Schoch S, Brandstätter JH, Regus-Leidig H. Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses. J Neurosci. Society for Neuroscience; 2017 Aug 16;37(33):7848–63.


Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ. Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis. Mol Neurobiol. Springer US; 2017 Jul 1;7(8):31–10.


Pitsch J, Becker AJ, Schoch S, Müller JA, de Curtis M, Gnatkovsky V. Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus. Epilepsia. 2017 May 24;54(Suppl. 1):1315.


Tognatta R, Sun W, Goebbels S, Nave K-A, Nishiyama A, Schoch S, Dimou L, Dietrich D. Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates. Glia. 2017 Feb;65(2):342–59.


Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz K, Remy S. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nat Neurosci. 2017 Jan;20(1):16-19.


Bohmbach K, Schwarz MK, Schoch S, Henneberger C. The structural and functional evidence for vesicular release from astrocytes in situ. Brain research bulletin. 2017;136, pp.65–75


Picher MM, Oprisoreanu A-M, Jung S, Michel K, Schoch S*, Moser T*. Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca(2+) Channel Subunit and Promote Its Membrane Expression. Front Cell Neurosci. 2017;11:160. (*corresponding author)


Ü Basmanav FB, Cau L, Tafazzoli A, Méchin M-C, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJP, Oprisoreanu A-M, Wehner M, Thiele H, Altmüller J, Nürnberg P, Swan D, Houniet D, Büchner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome. Am J Hum Genet. 2016 Dec 1;99(6):1292–304.


Robens BK, Grote A, Pitsch J, Schoch S, Cardoso C, Becker AJ. Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice. Neurobiology of Disease. 2016 Nov;95:134–44.


Sun W, Matthews EA, Nicolas V, Schoch S, Dietrich D. NG2 glial cells integrate synaptic input in global and dendritic calcium signals. eLife. 2016 Sep 19;5.


Robens BK, Gembé E, Fassunke J, Becker AJ, Schoch S, Grote A. Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas. Life Sci. Elsevier Inc; 2016 Jun 15;155:70–5.


Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus. Neuron. 2016 May 18;90(4):853–65.


Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS. Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. Springer Berlin Heidelberg; 2016 Mar 18;:1–12.


Woitecki AMH, Müller JA, van Loo KMJ, Sowade RF, Becker AJ, Schoch S. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J Neurosci. Society for Neuroscience; 2016 Mar 2;36(9):2561–70.


Grote A, Robens BK, Blumcke I, Becker AJ, Schoch S*, Gembé E. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Neurobiology of Disease. 2016 Feb;86:170–6. (*corresponding author)


Bungenberg J, Surano N, Grote A, Surges R, Pernhorst K, Hofmann A, Schoch S*, Helmstaedter C*, Becker AJ*. Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance. Neurobiology of Disease. 2016 Feb;86:121–30. (*equal contribution)


LaConte LEW, Chavan V, Liang C, Willis J, Schönhense E-M, Schoch S, Mukherjee K. CASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner. Cell Mol Life Sci. Springer International Publishing; 2016;:1–23.


Royeck M, Kelly T, Opitz T, Otte D-M, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H. Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci. Society for Neuroscience; 2015 Nov 18;35(46):15240–53.


Lal D, Steinbrücker S, Schubert J, Sander T, Becker F, Weber Y, Lerche H, Thiele H, Krause R, Lehesjoki A-E, Nürnberg P, Palotie A, Neubauer BA, Muhle H, Stephani U, Helbig I, Becker AJ, Schoch S, Hansen J, Dorn T, Hohl C, Lüscher N, Epicure consortium, EuroEPINOMICS-CoGIE consortium, Spiczak von S, Lemke JR. Investigation of GRIN2A in common epilepsy phenotypes. Epilepsy Res. 2015 Sep;115:95–9.


Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T. Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones. Proc Natl Acad Sci U S A. National Acad Sciences; 2015 Jun 16;112(24):E3141–9.


Dannenberg H, Pabst M, Braganza O, Schoch S, Niediek J, Bayraktar M, Mormann F, Beck H. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J Neurosci. Society for Neuroscience; 2015 Jun 3;35(22):8394–410.


Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 2015 Jun 3;86(5):1253–64.


Kulbida R, Wang Y, Mandelkow E-M, Schoch S, Becker AJ, Loo KMJ. Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Struct Funct. Springer Berlin Heidelberg; 2015 Apr 17;220(5):1–9.


Grote A, Schoch S, Becker AJ. Temporal lobe epilepsy: a unique window into living human brain epigenetic gene regulation. Brain. 2015 Mar;138(Pt 3):509–11.


Michel K, Müller JA, Oprisoreanu A-M, Schoch S. The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy. 2015 Feb 23;335(2):157–64.


Esposito L, Drexler JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten
C, Eis-Hübinger AM, Schoch S, Elger CE, Becker AJ, Niehusmann P. Large-scale
analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies.
Epilepsia. 2015 Feb;56(2):234-43.


van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nature Communications. 2015;6:8688.


Schoch S, Müller JA, Oprisoreanu AM. Liprins, ELKS, and RIM-BP Proteins. Reference Module in Biomedical Research. Elsevier Inc; 2015. 12 p.


Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O’Brien TJ, Petrovski S, Lehe von M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature Communications. 2015;6:6031.


Sišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, Kammer von der H, Remy S. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease. Neuron. 2014 Dec 3;84(5):1023–33.


Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl H-HM, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G, 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS, EPICURE Consortium, The EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Human Molecular Genetics. 2014 Nov 15;23(22):6069–80.


Weber N, Vieweg L, Henze F, Oprisoreanu A-M, Solinski HJ, Breit A, Fecher-Trost C, Schalkowsky P, Wilhelm B, Wennemuth G, Schoch S, Gudermann T, Boekhoff I. RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction. J Mol Cell Biol. 2014 Oct;6(5):434–7.


Basmanav FB, Oprisoreanu A-M, Pasternack SM, Thiele H, Fritz G, Wenzel J, Größer L, Wehner M, Wolf S, Fagerberg C, Bygum A, Altmüller J, Rütten A, Parmentier L, Shabrawi-Caelen El L, Hafner C, Nürnberg P, Kruse R, Schoch S, Hanneken S, Betz RC. Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease. Am J Hum Genet. 2014 Jan 2;94(1):135–43.


Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, Lehe von M, Hoffmann P, Cichon S, Schoch S, Becker AJ. Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi. Neurobiology of Disease. 2013 Dec;60:115–25.


Kasperaviciute D, Catarino CB, Matarin M, Leu C, Novy J, Tostevin A, Leal B, Hessel EVS, Hallmann K, Hildebrand MS, Dahl H-HM, Ryten M, Trabzuni D, Ramasamy A, Alhusaini S, Doherty CP, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Zumsteg D, Duncan S, Kälviäinen RK, Eriksson KJ, Kantanen A-M, Pandolfo M, Gruber-Sedlmayr U, Schlachter K, Reinthaler EM, Stogmann E, Zimprich F, Théâtre E, Smith C, O’Brien TJ, Meng Tan K, Petrovski S, Robbiano A, Paravidino R, Zara F, Striano P, Sperling MR, Buono RJ, Hakonarson H, Chaves J, Costa PP, Silva BM, da Silva AM, de Graan PNE, Koeleman BPC, Becker A, Schoch S, Lehe von M, Reif PS, Rosenow F, Becker F, Weber Y, Lerche H, Rössler K, Buchfelder M, Hamer HM, Kobow K, Coras R, Blumcke I, Scheffer IE, Berkovic SF, Weale ME, UK Brain Expression Consortium, Delanty N, Depondt C, Cavalleri GL, Kunz WS, Sisodiya SM. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain. 2013 Oct;136(Pt 10):3140–50.


Pernhorst K, Herms S, Hoffmann P, Cichon S, Schulz H, Sander T, Schoch S, Becker AJ, Grote A. TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue. Seizure. 2013 Oct;22(8):675–8.


Matthews EA, Schoch S, Dietrich D. Tuning local calcium availability: cell-type-specific immobile calcium buffer capacity in hippocampal neurons. J Neurosci. 2013 Sep 4;33(36):14431–45.


Fernández-Busnadiego R, Asano S, Oprisoreanu A-M, Sakata E, Doengi M, Kochovski Z, Zürner M, Stein V, Schoch S, Baumeister W, Lucić V. Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering. The Journal of Cell Biology. 2013 May 27;201(5):725–40.


Pernhorst K, van Loo KM, Lehe von M, Priebe L, Cichon S, Herms S, Hoffmann P, Helmstaedter C, Sander T, Schoch S, Becker AJ. Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue. Brain Research. 2013 Mar 6;1499:136–44.


Alvaréz-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. RIM3γ and RIM4γ are key regulators of neuronal arborization. J Neurosci. 2013 Jan 9;33(2):824–39.


Helmstaedter C, Mihov Y, Toliat MR, Thiele H, Nuernberg P, Schoch S, Surges R, Elger CE, Kunz WS, Hurlemann R. Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia. 2013 Jan;54(1):36–44.


Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ, Schoch S. The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J Neurosci. 2012 Sep 5;32(36):12384–95.


Hildenbrand S, Schoch S, Lehe von M, Surges R, Müller CE. Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human brain samples. ChemMedChem. 2012 Aug;7(8):1369–74.


Erdmann E, Rupprecht V, Matthews E, Kukley M, Schoch S, Dietrich D. Depression of release by mGluR8 alters Ca2+ dependence of release machinery. Cerebral Cortex. 2012 Jul;22(7):1498–509.


Surges R, Schoch S, Elger CE. Synaptic vesicle protein 2A. Z Epileptol. 2012 Jun 13;25(3):215–21.


van Loo KMJ, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). Journal of Biological Chemistry. 2012 May 4;287(19):15489–501.


Zürner M, Mittelstaedt T, tom Dieck S, Becker A, Schoch S. Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins. J Comp Neurol. 2011 Oct 15;519(15):3019–39.


Pernhorst K, Raabe A, Niehusmann P, van Loo KM, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ. Promoter Variants Determine γ-Aminobutyric Acid Homeostasis-Related Gene Transcription in Human Epileptic Hippocampi. J Neuropathol Exp Neurol. LWW; 2011;70(12):1080–8.


Niehusmann P, Mittelstaedt T, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ. Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis. Epilepsia. 2010 Oct 13;51(12):2478–83.


Mittelstaedt T, Alvaréz-Baron E, Schoch S. RIM proteins and their role in synapse function. Biological Chemistry. 2010 Jun;391(6):599–606.


Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A. Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro. J Neuropathol Exp Neurol. 2009 Oct;68(10):1136–46.


Zürner M, Schoch S. The mouse and human Liprin-α family of scaffolding proteins: Genomic organization, expression profiling and regulation by alternative splicing. Genomics [Internet]. 2009 Mar;93(3):243–53. Available from: http://www.sciencedirect.com/science/article/pii/S0888754308002541


Mittelsteadt T, Seifert G, Alvaréz-Baron E, Steinhäuser C, Becker AJ, Schoch S. Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain. J Comp Neurol. 2009 Feb 1;512(4):514–28.


Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen C-C, Campbell KP, Schoch S, Yaari Y, Beck H. Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci. 2008 Dec 3;28(49):13341–53.


Schoch S, Mittelstaedt T, Zürner M. Liprins, ELKS, and RIM-BP Proteins. In: Squire LR, editor. Encyclopedia of Neuroscience. 1st ed. Oxford: Academic Press; 2008. pp. 487–93.


Mittelstaedt T, Alvaréz-Baron E, Schoch S. Die Cytomatrix derpräsynaptischen Aktiven Zone: molekulare Organisation und Funktion. Neuroforum. 2008 Jul 15;08(3):217–23.


Alvaréz-Baron E, Bien CG, Schramm J, Elger CE, Becker AJ, Schoch S. Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. Epilepsy Res. 2008 Jul;80(1):93–7.


Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ. Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain. 2008 Jun 21;131(11):3034–50.


Mittelstaedt T, Schoch S. Structure and evolution of RIM-BP genes: identification of a novel family member. Gene. 2007 Nov 15;403(1-2):70–9.


Kirschstein T, Bauer M, Muller L, Ruschenschmidt C, Reitze M, Becker AJ, Schoch S, Beck H. Loss of Metabotropic Glutamate Receptor-Dependent Long-Term Depression via Downregulation of mGluR5 after Status Epilepticus. J Neurosci. 2007 Jul 18;27(29):7696–704.


Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ. Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiology of Disease. 2007 Jun;26(3):623–33.


Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, Schoch S, Becker AJ. Differential Pi3K-pathway Activation in Cortical Tubers and Focal Cortical Dysplasias with Balloon Cells. Brain Pathology. 2007 Apr;17(2):165–73.


Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A. National Acad Sciences; 2007 Feb 13;104(7):2525–30.


Majores M, Schoch S, Lie A, Becker AJ. Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia. 2007;48 Suppl 2(s2):4–12.


Schoch S*, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC*. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 Dec 13;25(24):5852–63. (*corresponding author)


Schoch S, Gundelfinger ED. Molecular organization of the presynaptic active zone. Cell Tissue Res. 2006 Nov;326(2):379–91.


Huang Y-Y, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9365–70.


Deák F, Schoch S, Liu X, Südhof TC, Kavalali ET. Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol. 2004 Nov;6(11):1102–8.


Calakos N, Schoch S, Südhof TC, Malenka RC. Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron. 2004 Jun 24;42(6):889–96.


Powell CM, Schoch S, Monteggia L, Barrot M, Matos MF, Feldmann N, Südhof TC, Nestler EJ. The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron. 2004 Apr 8;42(1):143–53.


Lonart G, Schoch S, Kaeser PS, Larkin CJ, Südhof TC, Linden DJ. Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell. 2003 Oct 3;115(1):49–60.


Castillo PE, Schoch S, Schmitz F, Südhof TC, Malenka RC. RIM1alpha is required for presynaptic long-term potentiation. Nature. 2002 Jan 17;415(6869):327–30.


Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC. RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature. 2002 Jan 17;415(6869):321–6.


Schoch S, Deák F, Königstorfer A, Mozhayeva M, Sara Y, Südhof TC, Kavalali ET. SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science. 2001 Nov 2;294(5544):1117–22.


Schoch S, Cibelli G, Magin A, Steinmüller L, Thiel G. Modular structure of cAMP response element binding protein 2 (CREB2). Neurochem Int. 2001 Jun;38(7):601–8.


Cibelli G, Schoch S, Thiel G. Nuclear targeting of cAMP response element binding protein 2 (CREB2). European Journal of Cell Biology. 1999 Sep;78(9):642–9.


Okamoto M, Schoch S, Südhof TC. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Journal of Biological Chemistry. 1999 Jun 25;274(26):18446–54.


Cibelli G*, Schoch S*, Pajunk H, Brand IA, Thiel G. A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element. Eur J Biochem. 1996 Apr 1;237(1):311–7. (*equal contribution)


Cibelli G, Jüngling S, Schoch S, Gerdes HH, Thiel G. Identification of a functional cAMP response element in the secretogranin II gene. Eur J Biochem. 1996 Feb 15;236(1):171–9.


Thiel G, Petersohn D, Schoch S. pHIVTATA-CAT, a versatile vector to study transcriptional regulatory elements in mammalian cells. Gene. 1996 Feb 12;168(2):173–6.


Schoch S, Cibelli G, Thiel G. Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. Journal of Biological Chemistry. 1996 Feb 9;271(6):3317–23.


Petersohn D, Schoch S, Brinkmann DR, Thiel G. The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. Journal of Biological Chemistry. 1995 Oct 13;270(41):24361–9.


Thiel G, Schoch S, Petersohn D. Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. Journal of Biological Chemistry. 1994 May 27;269(21):15294–301.


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