International League Against Epilepsy Consortium on Complex Epilepsies. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nat Genet. 2023 Sep;55(9):1471-1482. doi: 10.1038/s41588-023-01485-w. Epub 2023 Aug 31.
Schuch F, Walger L, Schmitz M, David B, Bauer T, Harms A, Fischbach L, Schulte F, Schidlowski M, Reiter J, Bitzer F, von Wrede R, Rácz A, Baumgartner T, Borger V, Schneider M, Flender A, Becker A, Vatter H, Weber B, Specht-Riemenschneider L, Radbruch A, Surges R, Rüber T. An open presurgery MRI dataset of people with epilepsy and focal cortical dysplasia type II. Sci Data. 2023 Jul 20;10(1):475. doi: 10.1038/s41597-023-02386-7.
Fischbach L, Bauer T, Diers K, Witt JA, Brugues M, Borger V, Schidlowski M, Rácz A, Baumgartner T, von Wrede R, Paech D, Weber B, Radbruch A, Vatter H, Becker AJ, Huppertz HJ, Helmstaedter C, Surges R, Reuter M, Rüber T. A novel geometry-based analysis of hippocampal morphometry in mesial temporal lobe epilepsy. Hum Brain Mapp. 2023 Jun 22. doi: 10.1002/hbm.26392. Online ahead of print.
Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 Jun 9;9(23):eabq7595. doi: 10.1126/sciadv.abq7595. Epub 2023 Jun 9.
Harms A, Bauer T, Witt JA, Baumgartner T, von Wrede R, Racz A, Ernst L, Becker AJ, Helmstaedter C, Surges R, Rüber T. Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits in the Long-term Course of Limbic Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2023 May 25;10(4):e200125. doi:
Witt JA, Becker AJ, Helmstaedter C.The multifactorial etiology of cognitive deficits in epilepsy and the neuropathology of mesial temporal lobe epilepsy beyond hyperphosphorylated tau. Alzheimers Dement. 2023 Apr 18. doi: 10.1002/alz.13085. Online ahead of print.
Walger L, Adler S, Wagstyl K, Henschel L, David B, Borger V, Hattingen E, Vatter H, Elger CE, Baldeweg T, Rosenow F, Urbach H, Becker A, Radbruch A, Surges R, Reuter M, Cendes F, Wang ZI, Huppertz HJ, Rüber T. Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice. Epilepsia. 2023 May;64(5):1093-1112. doi: 10.1111/epi.17522. Epub 2023 Mar 5.
Hanafy AS, Steinlein P, Pitsch J, Silva MH, Vana N, Becker AJ, Graham ME, Schoch S, Lamprecht A, Dietrich D. Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices. Nat Commun. 2023 Jan 30;14(1):481. doi: 10.1038/s41467-023-36070-6.
Kyriazi M, Müller P, Pitsch J, van Loo KMJ, Quatraccioni A, Opitz T, Schoch S, Becker AJ, Cases-Cunillera S. Neurochemical profile of BRAFV600E/AktT308D/S473D mouse gangliogliomas reveals impaired GABAergic system inhibition. Dev Neurosci. 2022 Dec 20. doi: 10.1159/000528587. Online ahead of print.
Royero P, Quatraccioni A, Früngel R, Silva MH, Bast A, Ulas T, Beyer M, Opitz T, Schultze JL, Graham ME, Oberlaender M, Becker A, Schoch S, Beck H. Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase. Cell Rep. 2022 Dec 6;41(10):111757. doi: 10.1016/j.celrep.2022.111757.
Maiseyeu I, Güresir Á, Vatter H, Herrlinger U, Becker A, Wach J, Güresir E. Preoperative Risk Stratification of Increased MIB-1 Labeling Index in Pituitary Adenoma: A Newly Proposed Prognostic Scoring System. J Clin Med. 2022 Dec 1;11(23):7151. doi: 10.3390/jcm11237151
Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A. Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types. Neuropathol Appl Neurobiol. 2022 Dec;48(7):e12847. doi: 10.1111/nan.12847. Epub 2022 Sep 16.
Nitsch L, Petzinna S, Zimmermann J, Getts DR, Becker A, Müller M. MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 Model. Neuromolecular Med. 2022 Dec;24(4):415-423. doi: 10.1007/s12017-022-08705-2. Epub 2022 Mar 3.
Reimers A, Helmstaedter C, Elger CE, Pitsch J, Hamed M, Becker AJ, Witt JA. Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy. Ann Neurol. 2022 Nov 21. doi: 10.1002/ana.26557. Online ahead of print.
Tröscher AR, Mair KM, de Juan LV, Köck U, Steinmaurer A, Baier H, Becker A, Blümcke I, Finzel M, Geis C, Höftberger R, Mawrin C, von Oertzen TJ, Pitsch J, Surges R, Voges B, Weis S, Winklehner M, Woermann F, Bauer J, Bien CG. Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex. Brain. 2022 Oct 31:awac404. doi: 10.1093/brain/awac404. Online ahead of print.
Hansen N, Widman G, Önder D, Schwing K, Leelaarporn P, Prusseit I, von Wrede R, Surges R, Becker AJ, Witt JA, Elger CE, Helmstaedter C. Increased T- and B-cells associated with the phenotype of autoimmune limbic encephalitis with mainly memory dysfunction. J Transl Autoimmun. 2022 Sep 28;5:100167.
Wach J, Hamed M, Lampmann T, Güresir Á, Schmeel FC, Becker AJ, Herrlinger U, Vatter H, Güresir E. MAC-spinal meningioma score: A proposal for a quick-to-use scoring sheet of the MIB-1 index in sporadic spinal meningiomas. Front Oncol. 2022 Aug 26;12:966581.
Wach J, Güresir Á, Vatter H, Herrlinger U, Becker A, Toma M, Hölzel M, Güresir E. Low-Dose Acetylsalicylic Acid Treatment in Non-Skull-Base Meningiomas: Impact on Tumor Proliferation and Seizure Burden. Cancers (Basel). 2022 Sep 1;14(17):4285.
Nitsch L, Petzinna S, Zimmermann J, Getts DR, Becker A, Müller M. Central role of B cells in interleukin-23 dependent neuroinflammation in the GF-IL23 model. Neuroreport. 2022 Sep 7;33(13):577-582.
Taube J, Witt JA, Grote A, Delev D, Enkirch J, Hattingen E, Becker AJ, Elger CE, Helmstaedter C. Preoperative and postoperative memory in epilepsy patients with ‘gliosis only’ versus hippocampal sclerosis: a matched case-control study. J Neurol Neurosurg Psychiatry. 2022 Aug 25:jnnp-2022-329224.
Grote A, Heiland DH, Taube J, Helmstaedter C, Ravi VM, Will P, Hattingen E, Schüre JR, Witt JA, Reimers A, Elger C, Schramm J, Becker AJ, Delev D. ‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy. Brain. 2022 Aug 18:awac293.
Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A. Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types. Neuropathol Appl Neurobiol. 2022 Aug 17:e12847.
Pohlentz MS, Müller P, Cases-Cunillera S, Opitz T, Surges R, Hamed M, Vatter H, Schoch S, Becker AJ, Pitsch J.Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy. PLoS One. 2022 Aug 16;17(8):e0271995.
Wach J, Lampmann T, Güresir Á, Vatter H, Herrlinger U, Becker A, Toma M, Hölzel M, Güresir E. Increased MIB-1 Labeling Index Is Associated with Abducens Nerve Morbidity in Primary Sporadic Petroclival Meningioma Surgery: Beyond Location and Approach. Curr Oncol. 2022 Jul 16;29(7):5026-5041.
Van Loo KMJ, Carvill GL, Becker AJ, Conboy K, Goldman AM, Kobow K, Lopes-Cendes I, Reid CA, van Vliet EA, Henshall DC. Epigenetic genes and epilepsy – emerging mechanisms and clinical applications. Nat Rev Neurol. 2022 Sep;18(9):530-543.
Borger V, Hamed M, Bahna M, Rácz Á, Ilic I, Potthoff AL, Baumgartner T, Rüber T, Becker A, Radbruch A, Mormann F, Surges R, Vatter H, Schneider M. Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long-term. Ann Clin Transl Neurol. 2022 Jul 1.
Baumgartner T, Pitsch J, Olaciregui-Dague K, Hoppe C, Racz A, Rüber T, Becker A, von Wrede R, Surges R. Seizure underreporting in LGI1 and CASPR2 antibody encephalitis. Epilepsia. 2022 Jun 23.
Silvennoinen K, Gawel K, Tsortouktzidis D, Pitsch J, Alhusaini S, van Loo KMJ, Picardo R, Michalak Z, Pagni S, Martins Custodio H, Mills J, Whelan CD, de Zubicaray GI, McMahon KL, van der Ent W, Kirstein-Smardzewska KJ, Tiraboschi E, Mudge JM, Frankish A, Thom M, Wright MJ, Thompson PM, Schoch S, Becker AJ, Esguerra CV, Sisodiya SM. SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility. Acta Neuropathol. 2022 Jul;144(1):107-127.
Rácz A, Hummel CA, Becker A, Helmstaedter C, Schuch F, Baumgartner T, von Wrede R, Borger V, Solymosi L, Surges R, Elger CE. Histopathologic Characterization and Neurodegenerative Markers in Patients With Limbic Encephalitis Undergoing Epilepsy Surgery. Front Neurol. 2022 Apr 15;13:859868.
Wach J, Lampmann T, Güresir Á, Vatter H, Herrlinger U, Becker A, Toma M, Hölzel M, Güresir E. Inflammatory Tumor Microenvironment in Cranial Meningiomas: Clinical Implications and Intraindividual Reproducibility. Diagnostics (Basel). 2022 Mar 30;12(4):853.
Müller JA, Betzin J, Santos-Tejedor J, Mayer A, Oprişoreanu AM, Engholm-Keller K, Paulußen I, Gulakova P, McGovern TD, Gschossman LJ, Schönhense E, Wark JR, Lamprecht A, Becker AJ, Waardenberg AJ, Graham ME, Dietrich D, Schoch S. A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Cell Rep. 2022 Apr 19;39(3):110696.
Strippel C, Herrera-Rivero M, Wendorff M, Tietz AK, Degenhardt F, Witten A, Schroeter C, Nelke C, Golombeck KS, Madlener M, Rüber T, Ernst L, Racz A, Baumgartner T, Widman G, Doppler K, Thaler F, Siebenbrodt K, Dik A, Kerin C, Räuber S, Gallus M, Kovac S, Grauer OM, Grimm A, Prüss H, Wickel J, Geis C, Lewerenz J, Goebels N, Ringelstein M, Menge T, Tackenberg B, Kellinghaus C, Bien CG, Kraft A, Zettl U, Ismail FS, Ayzenberg I, Urbanek C, Sühs KW, Tauber SC, Mues S, Körtvélyessy P, Markewitz R, Paliantonis A, Elger CE, Surges R, Sommer C, Kümpfel T, Gross CC, Lerche H, Wellmer J, Quesada CM, Then Bergh F, Wandinger KP, Becker AJ, Kunz WS, Meyer Zu Hörste G, Malter MP, Rosenow F, Wiendl H, Kuhlenbäumer G, Leypoldt F, Lieb W, Franke A, Meuth SG, Stoll M, Melzer N; German Network for Research on Autoimmune Encephalitis (GENERATE). A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies. Brain. 2022 Mar 28:awac119.
Nitsch L, Petzinna S, Zimmermann J, Getts DR, Becker A, Müller M. MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 Model. Neuromolecular Med. 2022 Mar 3.
Wach J, Lampmann T, Güresir Á, Vatter H, Herrlinger U, Becker A, Cases-Cunillera S, Hölzel M, Toma M, Güresir E. Proliferative Potential, and Inflammatory Tumor Microenvironment in Meningioma Correlate with Neurological Function at Presentation and Anatomical Location-From Convexity to Skull Base and Spine. Cancers (Basel). 2022 Feb 18;14(4):1033.
Tsortouktzidis D, Tröscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, van Loo KMJ. A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological Ca V 3.2 Channelopathies by Promoter-Mediated Transcription Control. Front Mol Neurosci. 2022 Jan 6;14:667143.
Harms A, Bauer T, Fischbach L, David B, Ernst L, Witt JA, Diers K, Baumgartner T, Weber B, Radbruch A, Becker AJ, Helmstaedter C, Reuter M, Elger CE, Surges R, Rüber T. Shape description and volumetry of hippocampus and amygdala in temporal lobe epilepsy – A beneficial combination with a clinical perspective. Epilepsy Behav. 2022 Mar 128:108560.
Zeyen T, Potthoff AL, Nemeth R, Heiland DH, Burger MC, Steinbach JP, Hau P, Tabatabai G, Glas M, Schlegel U, Grauer O, Krex D, Schnell O, Goldbrunner R, Sabel M, Thon N, Delev D, Clusmann H, Seidel C, Güresir E, Schmid M, Schuss P, Giordano FA, Radbruch A, Becker A, Weller J, Schaub C, Vatter H, Schilling J, Winkler F, Herrlinger U, Schneider M. Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial. Trials. 2022 Jan 19;23(1):57.
Wach J, Güresir Á, Borger V, Schuss P, Becker A, Coch C, Schmitz MT, Hölzel M, Toma M, Herrlinger U, Vatter H, Güresir E. Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma. J Neurooncol. 2022 Jan 156(2):365-375.
Cases-Cunillera S, van Loo KMJ, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, Borger V, Dietrich D, Schoch S, Becker AJ. Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss. Neuro Oncol. 2022 May 4;24(5):741-754.
Dik A, Widman G, Schulte-Mecklenbeck A, Witt JA, Pitsch J, Golombeck KS, Wagner J, Gallus M, Strippel C, Hansen N, Mönig C, Räuber S, Wiendl H, Elger CE, Surges R, Meuth SG, Helmstaedter C, Gross CC, Becker AJ, Melzer N. Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis. Ann Clin Transl Neurol. 2021 Dec;8(12):2289-2301.
Wach J, Lampmann T, Güresir Á, Vatter H, Becker AJ, Hölzel M, Toma M, Güresir E. Combining FORGE Score and Histopathological Diagnostic Criteria of Atypical Meningioma Enables Risk Stratification of Tumor Progression. Diagnostics (Basel). 2021 Oct 29;11(11):2011.
Salemdawod A, Wach J, Banat M, Borger V, Hamed M, Haberl H, Sassen R, Radbruch A, Becker AJ, Vatter H, Surges R, Sarikaya-Seiwert S. Predictors of postoperative long-term seizure outcome in pediatric patients with focal cortical dysplasia type II at a German tertiary epilepsy center. J Neurosurg Pediatr. 2021 Oct 15;29(1):83-91.
Schoch S, Quatraccioni A, Robens BK, Maresch R, van Loo KMJ, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. J Neurosci. 2021 Sep 29;41(39):8111-8125.
Reiter JT, David B, Enders S, Prillwitz CC, Bauer T, Atalay D, Tietze A, Kaindl AM, Keil V, Radbruch A, Weber B, Becker AJ, Elger CE, Surges R, Rüber T. Infratentorial MRI Findings in Rasmussen Encephalitis Suggest Primary Cerebellar Involvement. Neurol Neuroimmunol Neuroinflamm. 2021 Aug 13;8(6):e1058.
Wach J, Lampmann T, Güresir Á, Schuss P, Vatter H, Herrlinger U, Becker A, Hölzel M, Toma M, Güresir E. FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas. Cancers (Basel). 2021 Jul 20;13(14):3643.
Reimers A, Hummel CA, Eis-Hübinger AM, Surges R, Niehusmann P, Schoch S, Becker AJ, Pitsch J. Analysis of autoantibody spectrum and human herpesvirus 6 in adult patients with ‘early’ versus ‘late’ diagnosis of ‘possible limbic encephalitis’. Epilepsy Res. 2021 Oct 176:106698.
Stevelink R, Luykx JJ, Lin BD, Leu C, Lal D, Smith AW, Schijven D, Carpay JA, Rademaker K, Rodrigues Baldez RA, Devinsky O, Braun KPJ, Jansen FE, Smit DJA, Koeleman BPC; International League Against Epilepsy Consortium on Complex Epilepsies; Epi25 Collaborative. Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. Epilepsia. 2021 Jul 62(7):1518-1527.
Rácz A, Becker AJ, Quesada CM, Borger V, Vatter H, Surges R, Elger CE. Post-Surgical Outcome and Its Determining Factors in Patients Operated on With Focal Cortical Dysplasia Type II-A Retrospective Monocenter Study. Front Neurol. 2021 Jun 9;12:666056.
Tröscher AR, Sakaraki E, Mair KM, Köck U, Racz A, Borger V, Cloppenborg T, Becker AJ, Bien CG, Bauer J. T cell numbers correlate with neuronal loss rather than with seizure activity in medial temporal lobe epilepsy. Epilepsia. 2021 Jun 62(6):1343-1353.
Blümcke I, Coras R, Busch RM, Morita-Sherman M, Lal D, Prayson R, Cendes F, Lopes-Cendes I, Rogerio F, Almeida VS, Rocha CS, Sim NS, Lee JH, Kim SH, Baulac S, Baldassari S, Adle-Biassette H, Walsh CA, Bizzotto S, Doan RN, Morillo KS, Aronica E, Mühlebner A, Becker A, Cienfuegos J, Garbelli R, Giannini C, Honavar M, Jacques TS, Thom M, Mahadevan A, Miyata H, Niehusmann P, Sarnat HB, Söylemezoglu F, Najm I. Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial. Epilepsia. 2021 Jun;62(6):1416-1428.
Nitsch L, Petzinna S, Zimmermann J, Schneider L, Krauthausen M, Heneka MT, Getts DR, Becker A, Müller M. Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model. J Neuroinflammation. 2021 Apr 27;18(1):101.
David B, Kröll-Seger J, Schuch F, Wagner J, Wellmer J, Woermann F, Oehl B, Van Paesschen W, Breyer T, Becker A, Vatter H, Hattingen E, Urbach H, Weber B, Surges R, Elger CE, Huppertz HJ, Rüber T. External validation of automated focal cortical dysplasia detection using morphometric analysis. Epilepsia. 2021 Apr 62(4):1005-1021.
Helmstaedter C, Hansen N, Leelaarporn P, Schwing K, Oender D, Widman G, Racz A, Surges R, Becker A, Witt JA. Specific B- and T-cell populations are associated with cognition in patients with epilepsy and antibody positive and negative suspected limbic encephalitis. J Neurol. 2021 Feb;268(2):455-466.
von Wrede R, Jeub M, Ariöz I, Elger CE, von Voss H, Klein HG, Becker AJ, Schoch S, Surges R, Kunz WS. Novel KCNH1 Mutations Associated with Epilepsy: Broadening the Phenotypic Spectrum of KCNH1-Associated Diseases. Genes (Basel). 2021 Jan 21;12(2):132.
Rodríguez de Los Santos M, Rivalan M, David FS, Stumpf A, Pitsch J, Tsortouktzidis D, Velasquez LM, Voigt A, Schilling K, Mattei D, Long M, Vogt G, Knaus A, Fischer-Zirnsak B, Wittler L, Timmermann B, Robinson PN, Horn D, Mundlos S, Kornak U, Becker AJ, Schmitz D, Winter Y, Krawitz PM. A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014481118.
Broekaart DW, Bertran A, Jia S, Korotkov A, Senkov O, Bongaarts A, Mills JD, Anink JJ, Seco J, Baayen JC, Idema S, Chabrol E, Becker AJ, Wadman WJ, Tarragó T, Gorter JA, Aronica E, Prades R, Dityatev A, van Vliet EA.The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects. J Clin Invest. 2021 Jan 4;131(1):e138332.
Tsortouktzidis D, Schulz H, Hamed M, Vatter H, Surges R, Schoch S, Sander T, Becker AJ, van Loo KMJ. Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness. Epilepsia. 2021 Jan 62(1):e29-e34.
Kuehn JC, Meschede C, Helmstaedter C, Surges R, von Wrede R, Hattingen E, Vatter H, Elger CE, Schoch S, Becker AJ, Pitsch J. Adult-onset temporal lobe epilepsy suspicious for autoimmune pathogenesis: Autoantibody prevalence and clinical correlates. PLoS One. 2020 Oct 29;15(10):e0241289.
Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH; Project MinE ALS GWAS Consortium; International League Against Epilepsy Consortium on Complex Epilepsies. Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging. 2020 Aug;92:153.e1-153.e5.
Kobow K, Reid CA, van Vliet EA, Becker AJ, Carvill GL, Goldman AM, Hirose S, Lopes-Cendes I, Khiari HM, Poduri A, Johnson MR, Henshall DC. Epigenetics explained: a topic “primer” for the epilepsy community by the ILAE Genetics/Epigenetics Task Force. Epileptic Disord. 2020 Apr 1;22(2):127-141.
Hansen N, Önder D, Schwing K, Widman G, Leelaarporn P, Prusseit I, Surges R, Becker AJ, Witt JA, Helmstaedter C, Elger CE. CD19+ B-cells in autoantibody-negative limbic encephalitis. Epilepsy Behav. 2020 May;106:107016. doi: 10.1016/j.yebeh.2020.107016
Pitsch J, Kamalizade D, Braun A, Kuehn JC, Gulakova PE, Rüber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R, Elger CE, Hattingen E, Vatter H, Schoch S, Becker AJ. Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis. Ann Neurol. 2020 Jun;87(6):869-884.
Pensold D, Reichard J, Van Loo KMJ, Ciganok N, Hahn A, Bayer C, Liebmann L, Groß J, Tittelmeier J, Lingner T, Salinas-Riester G, Symmank J, Halfmann C, González-Bermúdez L, Urbach A, Gehrmann J, Costa I, Pieler T, Hübner CA, Vatter H, Kampa B, Becker AJ, Zimmer-Bensch G. DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons. Cereb Cortex. 2020 Jun 1;30(7):3921-3937.
Bauer T, Ernst L, David B, Becker AJ, Wagner J, Witt JA, Helmstaedter C, Weber B, Hattingen E, Elger CE, Surges R, Rüber T. Fixel-based analysis links white matter characteristics, serostatus and clinical features in limbic encephalitis. Neuroimage Clin. 2020 May 26;27:102289.
Kuehn JC, Scheuerle A, Bauer J, Becker AJ, Wirtz R, Lewerenz J. A 64-Year-Old Patient With a Mesiotemporal Mass and Symptomatic Epilepsy. Brain Pathol. 2020 Mar;30(2):413-414. doi: 10.1111/bpa.12818.
Serth J, Peters I, Dubrowinskaja N, Reese C, Albrecht K, Klintschar M, Lafos M, Grote A, Becker AJ, Hennenlotter J, Stenzl A, Tezval H, Kuczyk MA. Age-, tumor-, and metastatic tissue-associated DNA hypermethylation of a T-box brain 1 locus in human kidney tissue. Clin Epigenetics. 2020 Feb 18;12(1):33
van Loo KMJ, Becker AJ. Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies. Front Cell Neurosci. 2020 Jan 14;13:587.
Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH. Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course. Sci Rep. 2020 Jan 9;10(1):96.
Hansen N, Schwing K, Önder D, Widman G, Leelaarporn P, Prusseit I, Surges R, Melzer N, Gross C, Becker AJ, Witt JA, Elger CE, Helmstaedter C. High Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis. Epilepsy Behav. 2020 Jan;102:106682. doi: 10.1016
Schneider M, Borger V, Güresir Á, Becker AJ, Vatter H, Schuss P, Güresir E. High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma. Neurosurg Rev. 2019 Dec 13. doi: 10.1007/s10143-019-01222-0.
Senatorov VV Jr, Friedman AR, Milikovsky DZ, Ofer J, Saar-Ashkenazy R, Charbash A, Jahan N, Chin G, Mihaly E, Lin JM, Ramsay HJ, Moghbel A, Preininger MK, Eddings CR, Harrison HV, Patel R, Shen Y, Ghanim H, Sheng H, Veksler R, Sudmant PH, Becker AJ, Hart B, Rogawski MA, Dillin A, Friedman A, Kaufer D. Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction. Sci Transl Med. 2019 Dec 4;11(521):eaaw8283.
Reinhardt A, Stichel D, Schrimpf D, Koelsche C, Wefers AK, Ebrahimi A, Sievers P, Huang K, Casalini MB, Fernández-Klett F, Suwala A, Weller M, Gramatzki D, Felsberg J, Reifenberger G, Becker AJ, Hans VH, Prinz M, Staszewski O, Acker T, Dohmen H, Hartmann C, Paulus W, Heß K, Brokinkel B, Schittenhelm J, Buslei R, Deckert M, Mawrin C, Hewer E, Pohl U, Jaunmuktane Z, Brandner S, Unterberg A, Hänggi D, Platten M, Pfister SM, Wick W, Herold-Mende C, Korshunov A, Reuss DE, Sahm F, Jones DTW, Capper D, von Deimling A. Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities. Acta Neuropathol Commun. 2019 Oct 28;7(1):163. doi: 10.1186/s40478-019-0801-8.
Stevelink R, Pangilinan F, Jansen FE, Braun KPJ; International League Against Epilepsy Consortium on Complex Epilepsies, Molloy AM, Brody LC, Koeleman BPC. Assessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy. Mol Genet Metab Rep. 2019 Oct 11;21:100518.
Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D. Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathol. 2020 Jan;139(1):193-209
Schwarz N, Uysal B, Welzer M, Bahr JC, Layer N, Löffler H, Stanaitis K, Pa H, Weber YG, Hedrich UB, Honegger JB, Skodras A, Becker AJ, Wuttke TV, Koch H.
Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease. Elife. 2019 Sep 9;8:e48417. doi: 10.7554/eLife.48417.
Laaniste L, Srivastava PK, Stylianou J, Syed N, Cases-Cunillera S, Shkura K, Zeng Q, Rackham OJL, Langley SR, Delahaye-Duriez A, O’Neill K, Williams M, Becker AJ, Roncaroli F, Petretto E, Johnson MR. Integrated systems-genetic analyses reveal a network target for delaying glioma progression. Ann Clin Transl Neurol. 2019 Sep;6(9):1616-1638
Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker AJ, Campbell IL, Müller M. CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. BMol Neurobiol. 2019 Dec;56(12):7977-7993
Witt JA, Coras R, Becker AJ, Elger CE, Blümcke I, Helmstaedter C. When does conscious memory become dependent on the hippocampus? The role of memory load and the differential relevance of left hippocampal integrity for short- and long-term aspects of verbal memory performance. Brain Struct Funct. 2019 May;224(4):1599-1607.
Jeub M, Taha O, Opitz T, Racz I, Pitsch J, Becker AJ, Beck H. Partial sciatic nerve ligation leads to an upregulation of Ni2+-resistant T-type Ca2+ currents in capsaicin-responsive nociceptive dorsal root ganglion neurons. J Pain Res. 2019 Feb 11;12:635-647. doi: 10.2147/
van Loo KMJ, Rummel CK, Pitsch J, Müller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S. Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. J Neurosci. 2019 Apr 24;39(17):3175-3187.
Nass RD, Hansen N, Quesada C, Rüber T, Kornblum C, Zsurka G, Hermann P, Becker AJ, Gärtner F, Hattingen E, Block W, Steidl E, Elger CE, Surges R, Kunz WS. Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier. Seizure. 2019 Mar;66:1-3. doi: 10.1016/j.seizure.2019.01.029.
Schulz H, Ruppert AK, Zara F, Madia F, Iacomino M, S Vari M, Balagura G, Minetti C, Striano P, Bianchi A, Marini C, Guerrini R, Weber YG, Becker F, Lerche H, Kapser C, Schankin CJ, Kunz WS, Møller RS, Oliver KL, Bellows ST, Mullen SA, Berkovic SF, Scheffer IE, Caglayan H, Ozbek U, Hoffmann P, Schramm S, Tsortouktzidis D, Becker AJ, Sander T. No evidence for a BRD2 promoter hypermethylation in blood leukocytes of Europeans with juvenile myoclonic epilepsy. Epilepsia. 2019 May;60(5):e31-e36.
International League Against Epilepsy Consortium on Complex Epilepsies. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nat Commun. 2018 Dec 10;9(1):5269.
Hansen N, Widman G, Stuff S, Becker AJ, Witt JA, Ahmadzadehfar H, Helmstaedter C, Elger CE. Cancer frequency detected by positron emission tomography-computed tomography in limbic encephalitis. Epilepsy Behav. 2018 Dec;89:105-111.
Kölble K, Cross JH, Becker AJ, Blümcke I. A web-based diagnostic reference centre for the European Reference Network “EpiCare”: recommendations of the eNeuropathology working group. Epileptic Disord. 2018 Oct 1;20(5):339-345
Vogt VL, Witt JA, Delev D, Grote A, von Lehe M, Becker AJ, Schramm J, Elger CE, Helmstaedter C. Cognitive features and surgical outcome of patients with long-term epilepsy-associated tumors (LEATs) within the temporal lobe. Epilepsy Behav. 2018 Nov;88:25-32.
Pitsch J, Kuehn JC, Gnatkovsky V, Müller JA, van Loo KMJ, de Curtis M, Vatter H, Schoch S, Elger CE, Becker AJ. Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. SMol Neurobiol. 2019 Mar;56(3):1825-1840.
Rácz A, Müller AM, Schwerdt J, Becker AJ, Vatter H, Elger CE. Age at epilepsy onset in patients with focal cortical dysplasias, gangliogliomas and dysembryoplastic neuroepithelial tumours. Seizure. 2018 May;58:82-89.
Reinhardt A, Stichel D, Schrimpf D, Sahm F, Korshunov A, Reuss DE, Koelsche C, Huang K, Wefers AK, Hovestadt V, Sill M, Gramatzki D, Felsberg J, Reifenberger G, Koch A, Thomale UW, Becker AJ, Hans VH, Prinz M, Staszewski O, Acker T, Dohmen H, Hartmann C, Mueller W, Tuffaha MSA, Paulus W, Heß K, Brokinkel B, Schittenhelm J, Monoranu CM, Kessler AF, Loehr M, Buslei R, Deckert M, Mawrin C, Kohlhof P, Hewer E, Olar A, Rodriguez FJ, Giannini C, NageswaraRao AA, Tabori U, Nunes NM, Weller M, Pohl U, Jaunmuktane Z, Brandner S, Unterberg A, Hänggi D, Platten M, Pfister SM, Wick W, Herold-Mende C, Jones DTW, von Deimling A, Capper D. Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. Acta Neuropathol. 2018 Aug;136(2):273-291.
Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker AJ, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Müller HL, Rutkowski S, von Hoff K, Frühwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM. DNA methylation-based classification of central nervous system tumours. Nature. 2018 Mar 22;555(7697):469-474.
Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C. Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Mol Neurobiol. 2018 Sep;55(9):7500-7511.
Weitensteiner V, Zhang R, Bungenberg J, Marks M, Gehlen J, Ralser DJ, Hilger AC, Sharma A, Schumacher J, Gembruch U, Merz WM, Becker AJ, Altmüller J, Thiele H, Herrmann BG, Odermatt B, Ludwig M, Reutter H. Exome sequencing in syndromic brain malformations identifies novel mutations in ACTB, and SLC9A6, and suggests BAZ1A as a new candidate gene. Birth Defects Res. 2018 Apr 17;110(7):587-597
Hansen N, Ernst L, Rüber T, Widman G, Becker AJ, Elger CE, Helmstaedter C. Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy. Epilepsy Behav. 2018 Feb;79:93-99.
Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathol Appl Neurobiol. 2018 Feb;44(1):112-129.
Becker AJ, Beck H. New developments in understanding focal cortical malformations. Curr Opin Neurol. 2017 Dec 22.
Poulheim F, Esposito L, Elger CE, Eis-Hübinger AM, Becker AJ, Niehusmann P. Large-scale analysis of herpesviridae in epilepsy-patients with signs of autoimmune encephalitis. Seizure. 2017 Dec;53:100-102.
Schulz H, Ruppert AK, Herms S, Wolf C, Mirza-Schreiber N, Stegle O, Czamara D, Forstner AJ, Sivalingam S, Schoch S, Moebus S, Pütz B, Hillmer A, Fricker N, Vatter H, Müller-Myhsok B, Nöthen MM, Becker AJ, Hoffmann P, Sander T, Cichon S. Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nat Commun. 2017 Nov 15;8(1):1511.
Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783.
Pérez-Palma E, Helbig I, Klein KM, Anttila V, Horn H, Reinthaler EM, Gormley P, Ganna A, Byrnes A, Pernhorst K,
Toliat MR, Saarentaus E, Howrigan DP, Hoffman P, Miquel JF, De Ferrari GV, Nürnberg P, Lerche H, Zimprich F, Neubauer BA, Becker AJ, Rosenow F, Perucca E, Zara F, Weber YG, Lal D. Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies. J Med Genet. 2017 Sep;54(9):598-606.
Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D. TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. Sci Rep. 2017 Aug 9;7(1):7711.
Bauer J, Becker AJ, Elyaman W, Peltola J, Rüegg S, Titulaer MJ, Varley JA, Beghi E. Innate and adaptive immunity in human epilepsies. Epilepsia. 2017 Jul;58 Suppl 3:57-68.
Pitsch J, Becker AJ, Schoch S, Müller JA, de Curtis M, Gnatkovsky V. Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus. Epilepsia. 2017 Jul;58(7):1159-1171.
Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ. Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis. Mol Neurobiol. 2017 Jul 1.
Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker AJ, Ekström TJ, Almgren M, Fogdell-Hahn A. Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration. J Virol. 2017 May 12;91(11). pii: e02105-16.
Robens B, Becker AJ. Molecular rescue of Tsc1-ablated cortical tuber mice. Oncotarget. 2017 Jan 24;8(4):5678-5679.
Bungenberg J, Surano N, Grote A, Surges R, Pernhorst K, Hofmann A, Schoch S, Helmstaedter C, Becker AJ. Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance. Neurobiol Dis. 86: 121-130, 2016.
Grote A, Robens BK, Blümcke I, Becker AJ, Schoch S, Gembé E. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Neurobiol Dis. 86: 170-176, 2016.
Hölzel M, Landsberg J, Glodde N, Bald T, Rogava M, Riesenberg S, Becker A, Jönsson G, Tüting T. A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells. Cancer Res. 76(2): 251-263, 2016.
Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nat Neurosci. 19(2): 223-232, 2016.
Schurr J, Coras R, Rössler K, Pieper T, Kudernatsch M, Holthausen H, Winkler P, Woermann F, Bien CG, Polster T, Schulz R, Kalbhenn T, Urbach H, Becker A, Grunwald T, Huppertz HJ, Gil-Nagel A, Toledano R, Feucht M, Mühlebner A, Czech T, Blümcke I. Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy: A new clinico-pathological entity. Brain Pathol. 2016 Jan 7. doi: 10.1111/bpa.12347. [Epub ahead of print]
Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS. Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. 2016 Mar 18. [Epub ahead of print]
Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J Neurosci. 36(9): 2561-2570, 2016.
Hansen N, Widman G, Witt JA, Wagner J, Becker AJ, Elger CE, Helmstaedter C. Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis. Epilepsy Behav. 2016 Dec;65:18-24.
Robens BK, Grote A, Pitsch J, Schoch S, Cardoso C, Becker AJ. Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice. Neurobiol Dis. 2016 Nov;95:134-44.
Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS. Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. 2016 Aug;132(2):277-88.
Niehusmann P, Widman G, Eis-Hübinger AM, Greschus S, Robens BK, Grote A, Becker AJ. Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence? Neuropathology. 2016 Aug;36(4):376-80.
Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. Advances in the development of biomarkers for epilepsy. Lancet Neurol. 2016 Jul;15(8):843-856.
Robens BK, Gembé E, Fassunke J, Becker AJ, Schoch S, Grote A. Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas. Life Sci. 2016 Jun 15;155:70-5.
Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus. Neuron. 2016 May 18;90(4):853-65.
Golombeck KS, Bönte K, Mönig C, van Loo KM, Hartwig M, Schwindt W, Widman G, Lindenau M, Becker AJ, Glatzel M, Elger CE, Wiendl H, Meuth SG, Lohmann H, Gross CC, Melzer N. Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis. Neurol Neuroimmunol Neuroinflamm. 2016 Apr 29;3(3):e232.
Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J Neurosci. 2016 Mar 2;36(9):2561-70.
Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nat Neurosci. 2016 Feb;19(2):223-32.
Chen F, Rosiene J, Che A, Becker A, LoTurco J. Identification and relative quantification of phosphopeptides by a combination of multi-protease digestion and isobaric labeling. Development. 142(20): 3601-3611, 2015.
Esposito L, Drexler JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten C, Eis-Hübinger AM, Schoch S, Elger CE, Becker AJ, Niehusmann P. Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies. Epilepsia. 56(2):234-243, 2015.
Grote A, Schoch S, Becker AJ. Temporal lobe epilepsy: a unique window into living human brain epigenetic gene regulation. Brain. 138(Pt 3):509-511, 2015.
Johnson MR*, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PL, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O’Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ*, Petretto E*. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat Commun. 6:6031. doi: 10.1038/ncomms7031, 2015. (* co-corresponding authors)
Koelsche C, Hovestadt V, Jones DT, Capper D, Sturm D, Sahm F, Schrimpf D, Adeberg S, Böhmer K, Hagenlocher C, Mechtersheimer G, Kohlhof P, Mühleisen H, Beschorner R, Hartmann C, Braczynski AK, Mittelbronn M, Buslei R, Becker A, Grote A, Urbach H, Staszewski O, Prinz M, Hewer E, Pfister SM, von Deimling A, Reuss DE. Melanotic Tumors of the Nervous System are Characterized by Distinct Mutational, Chromosomal and Epigenomic Profiles. Brain Pathol. 25(2): 202-208, 2015.
Kuchukhidze G, Wieselthaler-Hölzl A, Drexel M, Unterberger I, Luef G, Ortler M, Becker AJ, Trinka E, Sperk G. Calcium-binding proteins in focal cortical dysplasia. Epilepsia. 56(8): 1207-1216, 2015.
Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM. Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Struct Funct. 220(5): 3067-3073, 2015.
Lal D, Pernhorst K, Klein KM, Reif P, Tozzi R, Toliat MR, Winterer G, Neubauer B, Nürnberg P, Rosenow F, Becker F, Lerche H, Kunz WS, Kurki MI, Hoffmann P, Becker AJ, Perucca E, Zara F, Sander T, Weber YG. Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy. Epilepsia. 56(9): e129-e133, 2015.
Lal D, Steinbrücker S, Schubert J, Sander T, Becker F, Weber Y, Lerche H, Thiele H, Krause R, Lehesjoki AE, Nürnberg P, Palotie A, Neubauer BA, Muhle H, Stephani U, Helbig I, Becker AJ, Schoch S, Hansen J, Dorn T, Hohl C, Lüscher N; Epicure consortium; EuroEPINOMICS-CoGIE consortium, von Spiczak S, Lemke JR. Investigation of GRIN2A in common epilepsy phenotypes. Epilepsy Res. 115:95-99, 2015.
Royeck M, Kelly T, Opitz T, Otte DM, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H. Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci. 2015 Nov 18;35(46):15240-53. doi: 10.1523/JNEUROSCI.0493-15.2015.
Sahm F, Schrimpf D, Olar A, Koelsche C, Reuss D, Bissel J, Kratz A, Capper D, Schefzyk S, Hielscher T, Wang Q, Sulman EP, Adeberg S, Koch A, Okuducu AF, Brehmer S, Schittenhelm J, Becker A, Brokinkel B, Schmidt M, Ull T, Gousias K, Friederike A, Lamszus KK, Debus J, Mawrin C, Kim YJ, Simon M, Ketter R, Paulus W, Aldape KD, Herold-Mende C, von Deimling A. TERT Promoter Mutations and Risk of Recurrence in Meningioma. J Natl Cancer Inst. 2015 Dec 13;108(5). pii: djv377. doi: 10.1093/jnci/djv377.
Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard JR, Friedman A, Kaufer D. Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis. 78:115-125, 2015.
van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat Commun. 2015 Oct 26;6:8688. doi: 10.1038/ncomms9688.
Witt JA, Coras R, Schramm J, Becker AJ, Elger CE, Blümcke I, Helmstaedter C. Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy. J Neurol. 2015 Oct;262(10):2214-24. doi: 10.1007/s00415-015-7831-3.
Chen F, Becker AJ, Loturco JJ. Contribution of tumor heterogeneity in a new animal model of CNS tumors. Mol Cancer Res. 12(5):742-753.
Chen F, Becker AJ, Loturco JJ. Sources of CNS tumor heterogeneity. Oncosci. 1(7):482-483.
Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ. WONOEP appraisal: new genetic approaches to study epilepsy. Epilepsia. 2014 Aug;55(8):1170-86.
Cendes F, Sakamoto AC, Spreafico R, Bingaman W, Becker AJ. Epilepsies associated with hippocampal sclerosis. Acta Neuropathol. 2014 Jul;128(1):21-37.
Huberfeld G, Becker AJ. Commentary: Morris-Coole/Epilepsia prize. Epilepsia. 2014 May;55(5):640-1.
Lukasiuk K, Becker AJ. Molecular biomarkers of epileptogenesis. Neurotherapeutics. 2014 Apr;11(2):319-23.
Fuchs A, König K, Heukamp LC, Fassunke J, Kirfel J, Huss S, Becker AJ, Büttner R, Majores M. Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer. Diagn Pathol. 9:48, 2014.
Koelsche C, Sahm F, Wöhrer A, Jeibmann A, Schittenhelm J, Kohlhof P, Preusser M, Romeike B, Dohmen-Scheufler H, Hartmann C, Mittelbronn M, Becker A, von Deimling A, Capper D. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 24(3):221-229, 2014
Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun. 5:4563. doi: 10.1038/ncomms5563, 2014.
Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G; The 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS; The EPICURE Consortium, The EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet. 23(22):6069-6080, 2014.
Sišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease. Neuron, 84(5):1023-1033, 2014.
Urbach H, Huppertz HJ, Schwarzwald R, Becker AJ, Wagner J, Bahri MD, Tschampa HJ. Is the type and extent of hippocampal sclerosis measurable on high-resolution MRI? Neuroradiology. 56(9):731-735, 2014.
Witt JA, Coras R, Schramm J, Becker AJ, Elger CE, Blümcke I, Helmstaedter C. The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy. Hippocampus. 24(4):446-454, 2014.
Japp A, Gielen GH, Becker AJ. Recent aspects of classification and epidemiology of epilepsy-associated tumors. Epilepsia. 2013 Dec;54 Suppl 9:5-11.
Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. RIM3γ and RIM4γ are key regulators of neuronal arborization. J Neurosci. 33(2):824-839, 2013.
Bien CG, Tiemeier H, Sassen R, Kuczaty S, Urbach H, von Lehe M, Becker AJ, Bast T, Herkenrath P, Karenfort M, Kruse B, Kurlemann G, Rona S, Schubert-Bast S, Vieker S, Vlaho S, Wilken B, Elger CE. Rasmussen encephalitis: Incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. Epilepsia. 54(3):543-550, 2013.
Bien CG, Raabe AL, Schramm J, Becker A, Urbach H, Elger CE. Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009. J Neurol Neurosurg Psychiatry. 84(1):54-61, 2013.
Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, von Lehe M, Hoffmann P, Cichon S, Schoch S, Becker AJ. Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi. Neurobiol Dis. 60:115-25, 2013.
Kasperaviciute D, Catarino CB, Matarin M, Leu C, Novy J, Tostevin A, Leal B, Hessel EV, Hallmann K, Hildebrand MS, Dahl HH, Ryten M, Trabzuni D, Ramasamy A, Alhusaini S, Doherty CP, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Zumsteg D, Duncan S, Kälviäinen RK, Eriksson KJ, Kantanen AM, Pandolfo M, Gruber-Sedlmayr U, Schlachter K, Reinthaler EM, Stogmann E, Zimprich F, Théâtre E, Smith C, O’Brien TJ, Meng Tan K, Petrovski S, Robbiano A, Paravidino R, Zara F, Striano P, Sperling MR, Buono RJ, Hakonarson H, Chaves J, Costa PP, Silva BM, da Silva AM, de Graan PN, Koeleman BP, Becker A, Schoch S, von Lehe M, Reif PS, Rosenow F, Becker F, Weber Y, Lerche H, Rössler K, Buchfelder M, Hamer HM, Kobow K, Coras R, Blumcke I, Scheffer IE, Berkovic SF, Weale ME; UK Brain Expression Consortium, Delanty N, Depondt C, Cavalleri GL, Kunz WS, Sisodiya SM. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain. 136(Pt 10):3140-3150, 2013.
Koelsche C, Sahm F, Wöhrer A, Jeibmann A, Schittenhelm J, Kohlhof P, Preusser M, Romeike B, Dohmen-Scheufler H, Hartmann C, Mittelbronn M, Becker A, von Deimling A, Capper D. BRAF mutated Pleomorphic Xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 24(3):221-229, 2013 .
Krestel H, Raffel S, von Lehe M, Jagella C, Moskau-Hartmann S, Becker A, Elger CE, Seeburg PH, Nirkko A. Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy. Neurobiol Dis. 56C:66-73, 2013.
Malter MP, Tschampa HJ, Helmstaedter C, Urbach H, von Lehe M, Becker A, Clusmann H, Elger CE, Bien CG. Outcome after epilepsy surgery in patients with MRI features of bilateral ammon’s horn sclerosis. Epilepsy Res. 105(1-2):150-157, 2013.
Niehusmann P, Becker AJ, Malter MP, Raabe A, Boström A, von der Brelie C. Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas. Epilepsy Res. 107(1-2):190-194, 2013
Pernhorst K, Herms S, Hoffmann P, Cichon S, Schulz H, Sander T, Schoch S, Becker AJ, Grote A. TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue. Seizure. 22(8):675-678, 2013.
Pernhorst K, van Loo KM, von Lehe M, Priebe L, Cichon S, Herms S, Hoffmann P, Helmstaedter C, Sander T, Schoch S, Becker AJ. Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue. Brain Res. 1499:136-144, 2013.
Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F, Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. Acta Neuropathol. 125(3):351-358, 2013.
Sahm F, Bissel J, Koelsche C, Schweizer L, Capper D, Reuss D, Böhmer K, Lass U, Göck T, Kalis K, Meyer J, Habel A, Brehmer S, Mittelbronn M, Jones DT, Schittenhelm J, Urbschat S, Ketter R, Heim S, Mawrin C, Hainfellner JA, Berghoff AS, Preusser M, Becker A, Herold-Mende C, Unterberg A, Hartmann C, Kickingereder P, Collins VP, Pfister SM, von Deimling A. AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry. Acta Neuropathol. 126(5):757-762, 2013.
Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P. Albumin storage in neoplastic astroglial elements of gangliogliomas. Seizure, 22(2):144-150, 2013.
Schweizer L, Koelsche C, Sahm F, Piro RM, Capper D, Reuss DE, Pusch S, Habel A, Meyer J, Göck T, Jones DT, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler OD, Pfister SM, von Deimling A. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 125(5):651-658, 2013.
Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y. Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo. J Physiol. 2012 Nov 15;590(22):5895-905.
Kaya M, Becker AJ, Gürses C. Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia. Epilepsia. 2012 Nov;53 Suppl 6:31-6.
Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ, Schoch S. The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J Neurosci. 2012 Sep 5;32(36):12384-95.
Gousias K, Becker AJ, Simon M, Niehusmann P. Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol. 2012 Sep;109(3):545-53.
Berson A, Barbash S, Shaltiel G, Goll Y, Hanin G, Greenberg DS, Ketzef M, Becker AJ, Friedman A, Soreq H. Cholinergic-associated loss of hnRNP-A/B in Alzheimer’s disease impairs cortical splicing and cognitive function in mice. EMBO Mol Med. 2012 Aug;4(8):730-42.
van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem. 2012 May 4;287(19):15489-501.
Bien CG, Vincent A, Barnett MH, Becker AJ, Blümcke I, Graus F, Jellinger KA, Reuss DE, Ribalta T, Schlegel J, Sutton I, Lassmann H, Bauer J. Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain. 2012 May;135(Pt 5):1622-38.
Aronica E, Becker AJ, Spreafico R. Malformations of cortical development. Brain Pathol. 2012 May;22(3):380-401.
Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P. Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions. Epilepsia. 2012 Mar;53(3):539-48.
Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci USA, 108(27):11256-11261, 2011.
Becker SJ, Matusch A, Becker JS, Wu B, Palm C, Becker AJ, Salber D. Mass Spectrometric Imaging (MSI) of metals for biomedical research. Int J Mass Spectrom, 307(1-3):3-15, 2011.
Blümcke, I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Özkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R. The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia, 52(1):158-174, 2011.
Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP. Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J Neurosci. 31(40):14291-14295, 2011.
Ketzef M, Kahn J, Weissberg I, Becker AJ, Friedman A, Gitler D. Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. Neuroscience, 189:108-122, 2011.
Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron, 70(2):252-265, 2011.
Pernhorst K, Raabe A, Niehusmann P, van Loo KMJ, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ. Promoter variants determine GABA-homeostasis related gene transcription in human epileptic hippocampi. J Neuropathol Exp Neurol, 70(12):1080-1088, 2011.
Schijns OE, Bien CG, Majores M, von Lehe M, Urbach H, Becker A, Schramm J, Elger CE, Clusmann H. Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis. Neurosurgery, 68(1):98-106, 2011.
Schönberger A, Gembe E, Grote A, Witt JA, Elger CE, Bien CG, Urbach H, Becker AJ, Niehusmann P. Genetic analysis of tuberous-sclerosis genes 1 and 2 in non-lesional focal epilepsy. Epilepsy Behav, 21(3):233-237, 2011.
Wilcke A, Ligges C, Burkhardt J, Alexander M, Wolf C, Quente E, Ahnert P, Hoffmann P, Becker A, Müller-Myhsok B, Cichon S, Boltze J, Kirsten H. Imaging genetics of FOXP2 in dyslexia. Eur J Hum Genet, in press, 2011.
Zürner M, Mittelstaedt T, tom Dieck S, Becker AJ, Schoch S. Differential spatiotemporal expression and subcellular localization of Liprin-a proteins indicate isoform specific functions. J Comp Neurol, 519(15):3019-3039, 2011.
Grote A, Kovacs A, Clusmann H, Becker AJ, Niehusmann P. Incidental pituicytoma after accidental head trauma – case report and review of literature. Clin Neuropathol, 29(3):127-33, 2010.
Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A, Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker AJ, De Jonghe P, Lerche H. Molecular correlates of age-dependent seizures in inherited neonatal-infantile epilepsy. Brain, 133:1403-1414, 2010.
Niehusmann P, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ. Presence of human herpes virus-6 DNA in temporal lobe epilepsy brain tissue of patients with history of encephalitis but not other pathologies. Epilepsia, 51(12):2478-2483, 2010.
Bien CG, Szinay M, Wagner J, Clusmann H, Becker AJ, Urbach H. Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies. Arch Neurol, 66(12):1491-1499, 2009.
Blümcke I, Kistner I, Clusmann H, Schramm J, Becker AJ, Elger C, Bien CG, Merschhemke M, Meencke HJ, Lehmann T, Buchfelder M, Weigel D, Buslei R, Stefan H, Pauli E, Hildebrandt M. Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies. Acta Neuropathol, 117(5):535-544, 2009.
Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J, Urbach H. Simple and Complex Dysembryoplastic Neuroepithelial Tumors (DNT): clinical profile, MRI and histopathology. Neuroradiology, 51(7):433-443, 2009.
ElSharawy A, Hundrieser B, Brosch M, Wittig M, Huse K, Platzer M, Becker AJ, Simon M, Rosenstiel P, Schreiber S, Krawczak M, Hampe J. Systematic evaluation of the effect of common SNPs on pre-mRNA splicing. Hum Mutat, 30(4):625-632, 2009.
Faber-Zuschratter H, Hüttmann K, Steinhäuser C, Becker A, Schramm J, Okafo U, Shanley D, Yilmazer-Hanke DM. Ultrastructural and functional characterization of satellitosis in the human lateral amygdala associated with Ammon’s horn sclerosis. Acta Neuropathol, 117(5):545-555, 2009.
Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A. Hamartin variants frequent in focal dysplasias and cortical tubers reveal reduced tuberin binding and aberrant subcellular distribution in vitro. J Neuropathol Exp Neurol, 68(10):1136-1146, 2009.
Marcelin B, Chauvière L, Becker A, Migliore M, Esclapez M, Bernard C. h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy. Neurobiol Dis, 33(3):436-447, 2009.
Mittelsteadt T, Seifert G, Alvárez-Barón E, Steinhäuser C, Becker AJ, Schoch S. Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain. J Comp Neurol, 512(4):514-528, 2009
Schönberger A, Niehusmann P, Urbach H, Majores M, Grote A, Holthausen H, Blümcke I, Deckert M, Becker AJ. Increased Frequency of Distinct TSC2 Allelic Variants in FCDs with Balloon Cells and Mineralization. Neuropathology, 5:559-565, 2009.
Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, Dornmair K, Wiendl H. CD8+ T cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain, 132(5):1236-1246, 2009.
Battaglia G, Becker AJ, LoTurco J, Represa A, Baraban SC, Roper SN, Vezzani A. Basic Mechanisms in MCD in Animal Models. Epileptic Disorders, 11:802-808, 2009.
Snoei J, Urbach H, Engels G, Fassunke J, von Lehe M, Becker AJ, Majores M. Genetic alterations of protein-o-mannosyltransferase-1 in glioneuronal and glial brain tumors with subarachnoid spread. Neuropathology. 29(2):116-124, 2009.
Alvarez-Barón E, Bien CG, Schramm J, Elger CE, Becker AJ, Schoch S. Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. Epilepsy Res, 80(1):93-97, 2008.
Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen CC, Campbell KP, Schoch S, Yaari Y, Beck H. Transcriptional upregulation of CaV3.2 mediates epileptogenesis in the pilocarpine epilepsy model. J Neurosci, 28(49):13341-13353, 2008.
Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ. Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain, 131:3034-3050, 2008.
Hoischen A, Ehrler M, Fassunke J, Simon M, Baudis M, Landwehr C, Raldwimmer B, Lichter B, Schramm J, Becker AJ, Weber RG. Comprehensive characterization of genomic aberrations in gangliogliomas by comparative genomic hybridization (CGH), array-based CGH and interphase-FISH. Brain Pathol, 18(3):326-337, 2008
Majores M, von Lehe M, Fassunke J, Schramm J, Becker AJ, Simon M. Tumor recurrence and malignant progression of gangliogliomas. Cancer, 113(12):3355-3363, 2008.
Aronica E, Boer K, Becker A, Redeker S, Spliet WGM, van Rijen PC, Wittink F, Breit T, Wadman WJ, Gorter JA. Gene expression profile analysis of epilepsy-associated gangliogliomas. Neuroscience, 151(1): 272-292, 2007.
Bien CG, Urbach H, Schramm J, Soeder BM, Becker AJ, Voltz R, Vincent A, Elger CE. Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology, 18;69(12):1236-1244, 2007.
Blümcke I, Pauli E, Clusmann H, Schramm J, Becker A, Elger C, Merschhemke M, Meencke HJ, Lehmann T, von Deimling A, Scheiwe C, Zentner J, Volk B, Romstock J, Stefan H, Hildebrandt M. A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol, 113(3):235-244, 2007.
Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Chen J, Reitze M, Becker AJ, Schoch S, Beck H. Loss of metabotropic glutamate receptor-dependent LTD via downregulation of mGluR5 following status epilepticus. J Neurosci, 27(29):7696-7704, 2007.
Kral T, von Lehe M, Podlogar M, Clusmann H, Sussmann P, Kurthen M, Becker A, Urbach H, Schramm J. Focal cortical dysplasia: Long-term seizure outcome after surgical treatment. J Neurol Neurosurg Psychiatry, 78(8): 853-856, 2007.
Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ. Functional role of mGluR1 and mGluR4 in pilocarpine induced temporal lobe epilepsy. Neurobiol Dis, 26(3), 623-633, 2007.
Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, Schoch S, Becker AJ. Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol, 17(2):165-173, 2007.
Schick V, Majores M, Koch A, Elger CE, Schramm J, Urbach H, Becker AJ. Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy associated glioneuronal lesions. Epilepsia, 48 Suppl 5:65-73, 2007.
Schick V, Majores M, Fassunke J, Engels G, Simon M, Elger CE, Becker AJ. Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions. Neuropathol Appl Neurobiol, 33(2):152-162, 2007
Stenzel W, Franitza M, Becker AJ, Montesinos-Rongen M, Lohr M, Lee JY, Rohn G, Miletic H, Deckert M. A 30-year-old patient with tuberous sclerosis. Brain Pathol, 17(3):333-334, 2007.
Urbach H, Binder D, von Lehe M, Podlogar M, Bien CG, Becker A, Schramm J, Kral T, Clusmann H. Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions. Seizure, 16(7):608-614, 2007.
Stuer C, Vilz B, Majores M, Becker A, Schramm J, Simon M. Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer, 110(12):2799-2808, 2007.
Yilmazer-Hanke DM, Faber-Zuschratter H, Blümcke I, Bickel M, Becker A, Mawrin C, Schramm J. Axo-somatic inhibition of projection neurons in the lateral nucleus of amygdala in human temporal lobe epilepsy: an ultrastructural study. Exp Brain Res, 177:384-399, 2007.
Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G. Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene, 26(7):1088-1097, 2007.
Majores M, Lie A, Schoch S, Becker AJ. Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia, 48 Suppl 2:4-12, 2007.
Baars C, Löscher W, Leeb T, Becker A, Potschka H. Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy. Eur J Pharmacol, 550:54-61, 2006.
Dupont P, Van Paesschen W, Palmini A, Ambayi R, Van Loon J, Goffin J, Weckhuysen S, Sunaert S, Thomas B, Demaerel P, Sciot R, Becker AJ, H. Vanbilloen H, Mortelmans L, Van Laere K. Ictal perfusion patterns associated with single MR-visible focal dysplastic lesions: implications for the non-invasive delineation of the epileptogenic zone. Epilepsia, 47(9):1550-1557, 2006.
ElSharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M, Becker A, Nürnberg P, Schreiber S, Hampe J. SNPSplicer – Systematic analysis of SNP-dependent splicing in genotyped cDNAs. Hum Mutat, 27:1129-1134, 2006.
Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Pääbo S, Khaitovich P. Systematic analysis of gene expression in human brains before and after death. Genome Biology, 6(13):R112, 2006.
Hamacher M, Apweiler R, Arnold G, Becker A, Bluggel M, Carrette O, Colvis C, Dunn MJ, Frohlich T, Fountoulakis M, van Hall A, Herberg F, Ji J, Kretzschmar H, Lewczuk P, Lubec G, Marcus K, Martens L, Palacios Bustamante N, Park YM, Pennington SR, Robben J, Stuhler K, Reidegeld KA, Riederer P, Rossier J, Sanchez JC, Schrader M, Stephan C, Tagle D, Thiele H, Wang J, Wiltfang J, Yoo JS, Zhang C, Klose J, Meyer HE. HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Proteomics, 6(18):4890-4898, 2006.
Rüschenschmidt C, Chen J, Becker A, Riazanski V, Beck H. Functional properties and oxidative modulation of A-type K+ currents in hippocampal granule cells of control and chronically epileptic rats. Eur J Neurosci, 23(3):675-685, 2006.
Schick V, Majores M, Engels G, Spitoni S, Koch A, Elger CE, Simon M, Knobbe C, Blümcke I, Becker AJ. Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias. Acta Neuropathol, 112(6):715-725, 2006.
Becker AJ. Neuropathology and classification of cortical malformations – where do they develop? Epilepsia, 47:949-951, 2006.
Becker AJ, Blümcke I, Urbach H, Hans V, Majores M. Molecular neuropathology of epilepsy-associated glioneuronal malformations. J Neuropathol Exp Neurol, 65(2):99-108, 2006.
Crino PB, Becker AJ. Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions. Epilepsia, 47(10):1608-1616, 2006.
Majores M, Schick V, Engels G, Fassunke J, Elger CE, Schramm J, Blümcke I, Becker AJ. Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions. Acta Neuropathol. 2005 Dec;110(6):537-46.
Chen J, Larionov S, Hoerold N, Ullmann C, Elger CE, Schramm J, Becker AJ. Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. Neurosci Lett, 375(3):192-197, 2005.
Fell J, Köhling R, Grunwald T, Klaver P, Dietl T, Schaller C, Becker A, Elger CE, Fernandez G. Phase-locking characteristics of limbic P3 responses in hippocampal sclerosis. Neuroimage, 24(4):980-989, 2005.
Majores M, Blümcke I, Urbach H, Meroni A, Hans V, Holthausen H, Elger CE, Schramm J, Galli C, Spreafico R, Wiestler OD, Becker AJ. Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells. J Neuropathol Exp Neurol, 64(7):629-637, 2005.
Majores M, Schick V, Engels G, Fassunke J, Elger CE, Schramm J, Blümcke I, Becker AJ. Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy associated glioneuronal lesions. Acta Neuropathol, 110:537-546, 2005.
Fassunke J, Blümcke I, Lahl R, Elger CE, Schramm J, Merkelbach-Bruse S, Mathiak M, Wiestler OD, Becker AJ. Analysis of chromosomal instability in focal cortical dysplasia of Taylor’s balloon cell type. Acta Neuropathol. 2004 Aug;108(2):129-34.
Bernard C, Anderson A, Becker A, Poolos N, Beck H, Johnston D. Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305(5683):532-535, 2004.
Fassunke J, Blümcke I, Lahl R, Elger CE, Schramm J, Merkelbach-Bruse S, Mathiak M, Wiestler OD, Becker AJ. Chromosomal instability at loci other than TSC1 is rare in focal cortical dysplasia of Taylor’s balloon cell type. Acta Neuropathol, 108(2):129-134, 2004.
Fassunke J, Majores M, Ullmann C, Elger CE, Schramm J, Wiestler OD, Becker AJ. In situ-RT and immuno-laser microdissection for mRNA analysis of individual cells isolated from epilepsy associated glioneuronal tumors. Lab Invest, 84(11): 1520-1525, 2004.
Fauser S, Becker A, Schulze-Bonhage A, Hildebrandt M, Tuxhorn I, Pannek HW, Lahl R, Schramm J, Blümcke I. CD34-immunoreactive balloon cells in cortical malformations. Acta Neuropathol, 108(4): 272-278, 2004.
Kam R, Chen J, Blümcke I, Normann S, Fassunke J, Elger CE, Schramm J, Wiestler OD, Becker AJ. The reelin pathway components disabled-1 and p35 in gangliogliomas – a mutation and expression analysis. Neuropathol Appl Neurobiol, 30: 225-232, 2004.
Rudlowski C, Moser M, Becker AJ, Rath W, Büttner R, Schröder W, Schurmann A. GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology, 66 (5):404-410, 2004.
Volk HA, Burkhardt K, Potschka H, Chen J, Becker A, Löscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123(3):751-759, 2004.
Majores M, Eils J, Wiestler OD, Becker AJ. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res, 60:173-178, 2004.
Schulte JH, Pitsch J, Becker AJ. Functional genomics and target gene validation in experimental and human disease. Drug Discovery Today: Technologies, 1(2):105-111, 2004.
Becker AJ, Chen J, Zien A, Sochivko D, Normann S, Schramm J, Elger CE, Wiestler OD, Blümcke I. Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci 18(10):2792-2802, 2003.
Ellerkmann RE, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 119:323-333, 2003.
Kulla A, Burkhardt K, Meyer-Puttlitz B, Teesalu T, Asser T, Wiestler OD, Becker AJ. Analysis of the TP53 gene in laser microdissected glioblastoma vasculature. Acta Neuopathol, 105(4):328-332, 2003.
Rudlowski C, Becker AJ, Schröder W, Rath W, Büttner R, Moser M. GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer. Am J Clin Pathol. 120(5):691-698, 2003.
Sochivko D, Chen J, Becker A, Beck H. Blocker resistant Ca2+ currents in rat CA1 hippocampal pyramidal neurons. Neuroscience 116:629–638, 2003.
Urbach H, Blümcke I, Becker A, Solymosi L. Störungen der kortikalen Entwicklung: Bildgebung und Klassifizierung. Klin Neuroradiol 13:163-172, 2003.
Becker AJ, Chen J, Paus S, Normann S, Beck H, Elger CE, Wiestler OD, Blümcke I. Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation. Neuroreport 13:1327-1333, 2002.
Becker AJ, Klein H, Baden T, Aigner L, Normann S, Elger CE, Schramm J, Wiestler OD, Blümcke I. Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. Acta Neuropathol 104(4):403-408, 2002.
Becker AJ, Urbach H, Scheffler B, Baden T, Normann S, Lahl R, Pannek HW, Tuxhorn I, Elger CE, Schramm J, Wiestler OD, Blümcke I. Focal cortical dysplasia of Taylor’s balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann Neurol 52:29-37, 2002.
Su H, Sochivko D, Becker A, Chen J, Jiang Y, Yaari Y, Beck H. Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J Neurosci 22:3645-3655, 2002.
Varlamov DA, Kudin AP, Vielhaber S, Schröder R, Sassen R, Becker A, Kunz D, Haug K, Rebstock J, Heils A, Elger CE, Kunz WS. Metabolic consequences of a novel missense mutation of the mtDNA CO I gene. Hum Mol Genet 11:1797-1805, 2002.
Becker AJ, Wiestler OD, Blümcke I. Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage. Prog Brain Res 135:161-173, 2002.
Becker AJ, Löbach M, Klein H, Normann S, Nöthen MM, von Deimling A, Mizuguchi M, Elger CE, Schramm J, Wiestler OD, Blümcke I. Mutational analysis of TSC1 and TSC2 genes in gangliogliomas. Neuropathol Appl Neurobiol, 27:105-114, 2001.
Blümcke I, Becker AJ, Normann S, Hans V, Riederer BM, Krajewski S, Wiestler OD, Reifenberger G. Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells. J Neuropathol Exp Neurol 60:984-993, 2001.
Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, Becker AJ. Activity-induced expression of common reference genes in individual CNS neurons. Lab Invest 81(6):913-916, 2001.
Dettmeyer R, Driever F, Becker A, Wiestler OD, Madea B. Fatal myeloencephalopathy due to accidental intrathecal vincristin administration – a report of two cases. J Forensic Sci 122 (1):60-64, 2001.
Riazanski V, Becker A, Chen J, Sochivko D, Lie A, Wiestler OD, Elger CE, Beck H. Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J Physiol 537:391-406, 2001.
Rudlowski C, Rath W, Becker AJ, Wiestler OD, Büttner R. Trastuzumab and breast cancer. New Engl J Med 345 (13):997-998, 2001.
Blümcke I, Becker A, Klein C, Scheiwe C, Lie AA, Beck H, Waha A, Friedel M, Kuhn R, Emson P, Elger C, Wiestler OD. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J Neuropathol Exp Neurol 59:1-10, 2000.
Busjahn A, Li GH, Faulhaber HD, Rosenthal M, Becker A, Jeschke E, Schuster H, Timmermann B, Hoehe MR, Luft FC. beta-2 Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size in Normal Twins. Hypertension 35:555-560, 2000.
Lie AA, Becker A, Behle K, Beck H, Malitschek B, Conn PJ, Kuhn R, Nitsch R, Plaschke M, Schramm J, Elger CE, Wiestler OD, Blümcke I. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol 47:26-35, 2000.
Becker AJ, Gillardon F, Blümcke I, Langendörfer D, Beck H, Wiestler OD. Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Res Mol Brain Res 67:172-176, 1999.
Becker AJ, Busjahn A, Faulhaber HD, Bähring S, Robertson J, Schuster H, Luft FC. Twin zygosity. Automated determination with microsatellites. J Reprod Med 42:260-266, 1997.
Busjahn A, Knoblauch H, Knoblauch M, Bohlender J, Menz M, Faulhaber HD, Becker A, Schuster H, Luft FC. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms, plasma levels, cardiac dimensions. A twin study. Hypertension 29:165-170, 1997.
Buchbeiträge
Becker AJ. Epilepsy-associated gangliogliomas: identification of genes with altered expression. Tumors of the Central Nervous System. Volume 5, Hayat MA (ed.). 2012, Volume 5, Part 5, 267-273 Springer Press.
Becker AJ, Wiestler OD, Figarella-Branger D, Blümcke I. Ganglioglioma and Gangliocytoma. In: WHO Classification of Tumours of the Central Nervous System, Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (eds.), pp. 103-105, IARC: Lyon, 2007.
Nakazato Y, Figarella-Branger D, Becker AJ, Scheithauer BW, Rosenblum MK. Papillary glioneuronal tumour. In: WHO Classification of Tumours of the Central Nervous System, Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (eds.), pp. 103-105, IARC: Lyon, 2007.
Seifert G, Becker AJ, Steinhäuser C. Combining patch-clamp techniques with RT-PCR. In: Advanced techniques for patch clamp analysis. Walz W, Boulton A, Baker G, eds. Humana Press, 301-330, 2002.
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