Galvis-Montes DS, van Loo KMJ, van Waardenberg AJ, Surges R, Schoch S, Becker AJ, Pitsch J. Highly dynamic inflammatory and excitability transcriptional profiles in hippocampal CA1 following status epilepticus. Sci Rep. 2023 Dec 14;13(1):22187. doi: 10.1038/s41598-023-49310-y.
Reimers A, Helmstaedter C, Elger CE, Pitsch J, Hamed M, Becker AJ, Witt JA. Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy. Ann Neurol. 2023 Mar;93(3):536-550. doi: 10.1002/ana.26557. Epub 2022 Dec 5.
Pohlentz MS, Müller P, Cases-Cunillera S, Opitz T, Surges R, Hamed M, Vatter H, Schoch S, Becker AJ, Pitsch J. Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy. PLoS One. 2022 Aug 16;17(8):e0271995. doi: 10.1371/journal.pone.0271995. PMID: 35972937;
Reimers A, Hummel CA, Eis-Hübinger AM, Surges R, Niehusmann P, Schoch S, Becker AJ*, Pitsch J*. Analysis of autoantibody spectrum and human herpesvirus 6 in adult patients with ‘early’ versus ‘late’ diagnosis of ‘possible limbic encephalitis’ (2021). Epilepsy Res 176:106698. doi: 10.1016/j.eplepsyres.2021.106698 (IF 2020: 3,045)
Pitsch J*, van Loo KMJ*, Gallus M*, Dik A*, Kamalizade D, Baumgart A, Gnatkovsky V, Opitz, T, Hicking G, Naik VA, Wachsmuth L, Faber C, Surges R, Kurts C, Schoch S, Melzer N, Becker AJ. CD8+ T-lymphocyte driven limbic encephalitis results in temporal lobe epilepsy (2021). Ann Neurol 89(4):666–85 (IF 2020: 10,422)
Kuehn JC, Meschede C, Helmstaedter C, Surges R, von Wrede R, Hattingen E, Vatter H, Elger CE, Schoch S, Becker AJ*, Pitsch J* (2020). Adult-onset temporal lobe epilepsy suspicious for autoimmune pathogenesis: antibody prevalence and clinical correlates. PLoS One 5(10):e0241289 (IF 2020: 3,240)
Pitsch J, Kamalizade D, Braun A, Kuehn JC, Gulakova PE, Ruber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R, Elger CE, Hattingen E, Vatter H, Schoch S, Becker AJ (2020). Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis. Ann Neurol 87:869-884 (IF: 10,422)
Pitsch J, Schoch S, Müller JA, de Curtis M, Gnatkovsky V, Becker AJ (2019). Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy. Mol Neurobiol 56, 1825-1840 (IF: 4,586)
Pitsch J, Becker AJ, Schoch S, Müller JA, de Curtis M, Gnatkovsky V (2017). Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus. Epilepsia 58: 1159-1171 (IF: 5,482)
Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ, Schoch S (2012). The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus. J Neurosci 32:12384-12395 (IF: 6,908)
Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ (2007). Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiol Dis 26, 623-633 (IF: 4,996)
Kim H, Melliti N, Breithausen E, Michel K, Colomer SF, Poguzhelskaya E, Nemcova P, Ewell L, Blaess S, Becker A, Pitsch J, Dietrich D, Schoch S. Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells. Brain. 2024 Mar 13:awae081. doi: 10.1093/brain/awae081.
Anders S, Breithausen B, Unichenko P, Herde MK, Minge D, Abramian A, Behringer C, Deshpande T, Boehlen A, Domingos C, Henning L, Pitsch J, Kim YB, Bedner P, Steinhäuser C, Henneberger C. Epileptic activity triggers rapid ROCK1-dependent astrocyte morphology changes. Glia. 2024 Mar;72(3):643-659. doi: 10.1002/glia.24495. Epub 2023 Nov 30.
Müller P, Dietrich D, Schoch S, Pitsch J, Becker AJ, Cases-Cunillera S. Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors. Neurobiol Dis. 2024 Jan;190:106364. doi: 10.1016/j.nbd.2023.106364. Epub 2023 Nov 24.
Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 Jun 9;9(23):eabq7595. doi: 10.1126/sciadv.abq7595. Epub 2023 Jun 9.
Hanafy AS, Steinlein P, Pitsch J, Silva MH, Vana N, Becker AJ, Graham ME, Schoch S, Lamprecht A, Dietrich D. Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices. Nat Commun. 2023 Jan 30;14(1):481. doi: 10.1038/s41467-023-36070-6.
Kyriazi M, Müller P, Pitsch J, van Loo KMJ, Quatraccioni A, Opitz T, Schoch S, Becker AJ, Cases-Cunillera S. Neurochemical Profile of BRAFV600E/AktT308D/S473D Mouse Gangliogliomas Reveals Impaired GABAergic System Inhibition. Dev Neurosci. 2023;45(2):53-65. doi: 10.1159/000528587.
Tröscher AR, Mair KM, Verdú de Juan L, Köck U, Steinmaurer A, Baier H, Becker A, Blümcke I, Finzel M, Geis C, Höftberger R, Mawrin C, von Oertzen TJ, Pitsch J, Surges R, Voges B, Weis S, Winklehner M, Woermann F, Bauer J, Bien CG. Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex. Brain. 2023 Apr 19;146(4):1436-1452. doi: 10.1093/brain/awac404.
Barker-Haliski M, Pitsch J, Galanopoulou AS, Köhling R. A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3-WG1C: Phenotyping working group of the ILAE/AES joint translational task force. Epilepsia Open. 2022 Dec 2. doi: 10.1002/epi4.12676.
Baumgartner T, Pitsch J, Olaciregui-Dague K, Hoppe C, Racz A, Rüber T, Becker A, von Wrede R, Surges R. Seizure underreporting in LGI1 and CASPR2 antibody encephalitis. Epilepsia. 2022 Sep;63(9):e100-e105. doi: 10.1111/epi.17338. Epub 2022 Jul 4. PMID: 35735209.
Silvennoinen K, Gawel K, Tsortouktzidis D, Pitsch J, Alhusaini S, van Loo KMJ, Picardo R, Michalak Z, Pagni S, Martins Custodio H, Mills J, Whelan CD, de Zubicaray GI, McMahon KL, van der Ent W, Kirstein-Smardzewska KJ, Tiraboschi E, Mudge JM, Frankish A, Thom M, Wright MJ, Thompson PM, Schoch S, Becker AJ, Esguerra CV, Sisodiya SM. SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility. Acta Neuropathol. 2022 Jul;144(1):107-127. doi: 10.1007/s00401-022-02429-0. Epub 2022 May 12.
Cases-Cunillera S, van Loo KMJ, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, Borger V, Dietrich D, Schoch S, Becker AJ. Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss. Neuro Oncol. 2022 May 4;24(5):741-754. doi: 10.1093/neuonc/noab268.
Matthews EA, Sun W, McMahon SM, Doengi M, Halka L, Anders S, Muller JA, Steinlein P, Vana S, van Dyk G, Pitsch J, Becker AJ, Pfeifer A, Kavalali ET, Lamprecht A, Henneberger C, Stein V, Schoch S, Dietrich D (2022). Optical Analysis of Glutamate Spread in the Neuropil. Cereb Cortex. doi: 10.1093/cercor/bhab440
Dik A, Widman G, Schulte-Mecklenbeck A, Witt JA, Pitsch J, Golombeck KS, Wagner J, Gallus M, Strippel C, Hansen N, Mönig C, Räuber S, Wiendl H, Elger CE, Surges R, Meuth SG, Helmstaedter C, Gross CC, Becker AJ, Melzer N. Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis. Ann Clin Transl Neurol. 2021 Dec;8(12):2289-2301. doi: 10.1002/acn3.51486. Epub 2021 Nov 28.
Lévesque M, Biagini G, de Curtis M, Gnatkovsky V, Pitsch J, Wang S, Avoli M. The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches. Neurosci Biobehav Rev. 2021 Nov;130:274-291. doi: 10.1016/j.neubiorev.2021.08.020.
Schoch S, Quatraccioni A, Robens BK, Maresch R, van Loo KMJ, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. J Neurosci. 2021 Sep 29;41(39):8111-8125. doi: 10.1523/JNEUROSCI.0352-21.2021
Rodríguez de Los Santos M, Rivalan M, David FS, Stumpf A, Pitsch J, Tsortouktzidis D, Velasquez LM, Voigt A, Schilling K, Mattei D, Long M, Vogt G, Knaus A, Fischer-Zirnsak B, Wittler L, Timmermann B, Robinson PN, Horn D, Mundlos S, Kornak U, Becker AJ, Schmitz D, Winter Y, Krawitz PM. A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014481118. doi: 10.1073/pnas.2014481118
Cases-Cunillera S, van Loo KMJ, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni S, Borger V, Dietrich D, Schoch S, Becker AJ (2021). Heterogeneity and excitability of BRAFV600E-induced tumors is determined by PI3K/mTOR-signaling state and Trp53-loss. Neuro-oncology. doi.org/10.1093/neuonc/noab268
Dik A, Widman G, Schulte-Mecklenbeck A, Witt JA, Pitsch J, Golombeck KS, Wagner J, Gallus M, Strippel C, Hansen N, Monig C, Rauber S, Wiendl H, Elger CE, Surges R, Meuth SG, Helmstaedter C, Gross CC, Becker AJ, Melzer N (2021). Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis. Ann Clin Transl Neurol 8(12): 2289-2301
Schoch S, Quatraccioni A, Robens BK, Maresch R, van Loo KMJ, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ (2021). Ste20-like kinase is critical for inhibitory synapse maintenance and its deficiency confers a developmental dendritopathy. J Neurosci. doi: 10.1523/JNEUROSCI.0352-21.2021 (IF 2020: 6,167)
Levesque M, Biagini G, de Curtis M, Gnatkovsky V, Pitsch J, Wang S, Avoli M (2021). The Pilocarpine Model of Mesial Temporal Lobe Epilepsy: Over One Decade Later, with More Rodent Species and New Investigative Approaches. Neurosci Biobehav Rev. doi: 10.1016/j.neubiorev.2021.08.020 (IF 2020: 8,989)
de los Santos RM, Rivalan M, David FS, Stumpf A, Pitsch J, Tsortouktzidis D, Moreno Velasquez L, Voigt A, Schilling K, Mattei D, Long M, Vogt G, Knaus A, Fischer-Zirnsak B, Wittler L, Timmermann B, Robinson PN, Horn D, Mundlos S, Kornak U, Becker AJ, Schmitz D, Winter Y, Krawitz PM (2020). A CRISPR-Cas9–engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proc. Natl. Acad. Sci. U.S.A 118(2):e2014481118 (IF 2020: 11,205)
Jeub M, Taha O, Opitz T, Racz I, Pitsch J, Becker A, Beck H (2019). Partial sciatic nerve ligation leads to an upregulationof Ni2+-resistant T-type Ca2+ currents in capsaicin-responsive nociceptive dorsal root ganglion neurons. J Pain Res 12: 1-13 (IF: 4,621)
van Loo KMJ, Rummel CK, Pitsch J, Muller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S (2019). Calcium Channel Subunit alpha2delta4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. J Neurosci 39(17): 3175-3187 (IF: 5,673)
Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H (2018). Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy. J Neurosci 38(24): 5596-5605 (IF: 6,02)
Kovacevic J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, Remmelink E, Koopmans B, Crowley J, Cornelisse LN, Sullivan PF, Schoch S, Toonen RF, Stiedl O, Verhage M (2018). Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy. Brain 141(5): 1350-1374 (IF: 11,236)
Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C (2018). Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Mol Neurobiol 55(9): 7500-7511 (IF: 4,586)
Taha O, Opitz T, Mueller M, Pitsch J, Becker A, Evert B. O.,Beck H, Jeub M (2017). Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons. Exp Neurol 297: 25-35 (IF: 4,483)
Robens BK, Grote A, Pitsch J, Schoch S, Cardoso C, Becker AJ (2016) Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice. Neurobiol Dis 95:134-144 (IF: 5,02)
Royeck M, Kelly T, Opitz T, Otte DM, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H (2015) Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci 35:15240-15253 (IF: 5,924)
van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ (2015). Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat Commun 6: 8688 (IF: 11,329)
Siskova Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S (2014). Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease. Neuron 84(5): 1023-1033 (IF: 13,436)
Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y (2012). Zinc Induces Long-Term Upregulation of T-Type Calcium Current in Hippocampal Neurons in Vivo. J Physiol 590:5895-905 (IF: 4,38)
Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP (2011). Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J Neurosci 31:14291-14295 (IF: 7,115)
Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A (2011). Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A 108:11256-11261 (IF: 10,975)
Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A, Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker AJ, De Jonghe P, Lerche H (2010). Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy. Brain 133:1403-1414 (IF: 10,528)
Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen CC, Campbell KP, Schoch S, Yaari Y, Beck H (2008). Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci 28, 13341-13353 (IF: 7,452)
Eckhardt M, Hedayati KK, Pitsch J, Lullmann-Rauch R, Beck H, Fewou SN, Gieselmann V (2007). Sulfatide storage in neurons causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy. J Neurosci 27, 9009-9021 (IF: 7,490)
Chen J, Larionov S, Pitsch J, Hoerold N, Ullmann C, Elger CE, Schramm J, Becker AJ (2005). Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. Neurosci Lett 375, 192-197 (IF: 1,898)
Schulte JH, Pitsch J, Becker AJ (2004). Functional genomics and target gene validation in experimental and human disease. Drug Discovery Today: Technologies 1, 105-111 (IF: 6,928)