Publications

Hansen N, Ernst L, Rüber T, Widman G, Becker AJ, Elger CE, Helmstaedter C. Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy. Epilepsy Behav. 2018 Feb;79:93-99.


Becker AJ. Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis. Neuropathol Appl Neurobiol. 2018 Feb;44(1):112-129.


Becker AJ, Beck H. New developments in understanding focal cortical malformations. Curr Opin Neurol. 2017 Dec 22.


Poulheim F, Esposito L, Elger CE, Eis-Hübinger AM, Becker AJ, Niehusmann P. Large-scale analysis of herpesviridae in epilepsy-patients with signs of autoimmune encephalitis. Seizure. 2017 Dec;53:100-102.


Schulz H, Ruppert AK, Herms S, Wolf C, Mirza-Schreiber N, Stegle O, Czamara D, Forstner AJ, Sivalingam S, Schoch S, Moebus S, Pütz B, Hillmer A, Fricker N, Vatter H, Müller-Myhsok B, Nöthen MM, Becker AJ, Hoffmann P, Sander T, Cichon S. Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nat Commun. 2017 Nov 15;8(1):1511.


Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783.


Pérez-Palma E, Helbig I, Klein KM, Anttila V, Horn H, Reinthaler EM, Gormley P, Ganna A, Byrnes A, Pernhorst K,
Toliat MR, Saarentaus E, Howrigan DP, Hoffman P, Miquel JF, De Ferrari GV, Nürnberg P, Lerche H, Zimprich F, Neubauer BA, Becker AJ, Rosenow F, Perucca E, Zara F, Weber YG, Lal D. Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies. J Med Genet. 2017 Sep;54(9):598-606.


Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D. TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. Sci Rep. 2017 Aug 9;7(1):7711.


Bauer J, Becker AJ, Elyaman W, Peltola J, Rüegg S, Titulaer MJ, Varley JA, Beghi E. Innate and adaptive immunity in human epilepsies. Epilepsia. 2017 Jul;58 Suppl 3:57-68.


Pitsch J, Becker AJ, Schoch S, Müller JA, de Curtis M, Gnatkovsky V. Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus. Epilepsia. 2017 Jul;58(7):1159-1171.


Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ. Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis. Mol Neurobiol. 2017 Jul 1.


Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker AJ, Ekström TJ, Almgren M, Fogdell-Hahn A. Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration. J Virol. 2017 May 12;91(11). pii: e02105-16.


Robens B, Becker AJ. Molecular rescue of Tsc1-ablated cortical tuber mice. Oncotarget. 2017 Jan 24;8(4):5678-5679.


Bungenberg J, Surano N, Grote A, Surges R, Pernhorst K, Hofmann A, Schoch S, Helmstaedter C, Becker AJ. Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance. Neurobiol Dis. 86: 121-130, 2016.


Grote A, Robens BK, Blümcke I, Becker AJ, Schoch S, Gembé E. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Neurobiol Dis. 86: 170-176, 2016.


Hölzel M, Landsberg J, Glodde N, Bald T, Rogava M, Riesenberg S, Becker A, Jönsson G, Tüting T. A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells. Cancer Res. 76(2): 251-263, 2016.


Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nat Neurosci. 19(2): 223-232, 2016.


Schurr J, Coras R, Rössler K, Pieper T, Kudernatsch M, Holthausen H, Winkler P, Woermann F, Bien CG, Polster T, Schulz R, Kalbhenn T, Urbach H, Becker A, Grunwald T, Huppertz HJ, Gil-Nagel A, Toledano R, Feucht M, Mühlebner A, Czech T, Blümcke I. Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy: A new clinico-pathological entity. Brain Pathol. 2016 Jan 7. doi: 10.1111/bpa.12347. [Epub ahead of print]


Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS. Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. 2016 Mar 18. [Epub ahead of print]


Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J Neurosci. 36(9): 2561-2570, 2016.


Hansen N, Widman G, Witt JA, Wagner J, Becker AJ, Elger CE, Helmstaedter C. Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis. Epilepsy Behav. 2016 Dec;65:18-24.


Robens BK, Grote A, Pitsch J, Schoch S, Cardoso C, Becker AJ. Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice. Neurobiol Dis. 2016 Nov;95:134-44.


Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS. Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. 2016 Aug;132(2):277-88.


Niehusmann P, Widman G, Eis-Hübinger AM, Greschus S, Robens BK, Grote A, Becker AJ. Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence? Neuropathology. 2016 Aug;36(4):376-80.


Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H. Advances in the development of biomarkers for epilepsy. Lancet Neurol. 2016 Jul;15(8):843-856.


Robens BK, Gembé E, Fassunke J, Becker AJ, Schoch S, Grote A. Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas. Life Sci. 2016 Jun 15;155:70-5.


Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus. Neuron. 2016 May 18;90(4):853-65.


Golombeck KS, Bönte K, Mönig C, van Loo KM, Hartwig M, Schwindt W, Widman G, Lindenau M, Becker AJ, Glatzel M, Elger CE, Wiendl H, Meuth SG, Lohmann H, Gross CC, Melzer N. Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis. Neurol Neuroimmunol Neuroinflamm. 2016 Apr 29;3(3):e232.


Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S. Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. J Neurosci. 2016 Mar 2;36(9):2561-70.


Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nat Neurosci. 2016 Feb;19(2):223-32.


Chen F, Rosiene J, Che A, Becker A, LoTurco J. Identification and relative quantification of phosphopeptides by a combination of multi-protease digestion and isobaric labeling. Development. 142(20): 3601-3611, 2015.


Esposito L, Drexler JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten C, Eis-Hübinger AM, Schoch S, Elger CE, Becker AJ, Niehusmann P. Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies. Epilepsia. 56(2):234-243, 2015.


Grote A, Schoch S, Becker AJ. Temporal lobe epilepsy: a unique window into living human brain epigenetic gene regulation. Brain. 138(Pt 3):509-511, 2015.


Johnson MR*, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PL, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O’Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ*, Petretto E*. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat Commun. 6:6031. doi: 10.1038/ncomms7031, 2015. (* co-corresponding authors)


Koelsche C, Hovestadt V, Jones DT, Capper D, Sturm D, Sahm F, Schrimpf D, Adeberg S, Böhmer K, Hagenlocher C, Mechtersheimer G, Kohlhof P, Mühleisen H, Beschorner R, Hartmann C, Braczynski AK, Mittelbronn M, Buslei R, Becker A, Grote A, Urbach H, Staszewski O, Prinz M, Hewer E, Pfister SM, von Deimling A, Reuss DE. Melanotic Tumors of the Nervous System are Characterized by Distinct Mutational, Chromosomal and Epigenomic Profiles. Brain Pathol. 25(2): 202-208, 2015.


Kuchukhidze G, Wieselthaler-Hölzl A, Drexel M, Unterberger I, Luef G, Ortler M, Becker AJ, Trinka E, Sperk G. Calcium-binding proteins in focal cortical dysplasia. Epilepsia. 56(8): 1207-1216, 2015.


Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM. Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice. Brain Struct Funct. 220(5): 3067-3073, 2015.


Lal D, Pernhorst K, Klein KM, Reif P, Tozzi R, Toliat MR, Winterer G, Neubauer B, Nürnberg P, Rosenow F, Becker F, Lerche H, Kunz WS, Kurki MI, Hoffmann P, Becker AJ, Perucca E, Zara F, Sander T, Weber YG. Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy. Epilepsia. 56(9): e129-e133, 2015.


Lal D, Steinbrücker S, Schubert J, Sander T, Becker F, Weber Y, Lerche H, Thiele H, Krause R, Lehesjoki AE, Nürnberg P, Palotie A, Neubauer BA, Muhle H, Stephani U, Helbig I, Becker AJ, Schoch S, Hansen J, Dorn T, Hohl C, Lüscher N; Epicure consortium; EuroEPINOMICS-CoGIE consortium, von Spiczak S, Lemke JR. Investigation of GRIN2A in common epilepsy phenotypes. Epilepsy Res. 115:95-99, 2015.


Royeck M, Kelly T, Opitz T, Otte DM, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H. Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci. 2015 Nov 18;35(46):15240-53. doi: 10.1523/JNEUROSCI.0493-15.2015.


Sahm F, Schrimpf D, Olar A, Koelsche C, Reuss D, Bissel J, Kratz A, Capper D, Schefzyk S, Hielscher T, Wang Q, Sulman EP, Adeberg S, Koch A, Okuducu AF, Brehmer S, Schittenhelm J, Becker A, Brokinkel B, Schmidt M, Ull T, Gousias K, Friederike A, Lamszus KK, Debus J, Mawrin C, Kim YJ, Simon M, Ketter R, Paulus W, Aldape KD, Herold-Mende C, von Deimling A. TERT Promoter Mutations and Risk of Recurrence in Meningioma. J Natl Cancer Inst. 2015 Dec 13;108(5). pii: djv377. doi: 10.1093/jnci/djv377.


Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard JR, Friedman A, Kaufer D. Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis. 78:115-125, 2015.


van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat Commun. 2015 Oct 26;6:8688. doi: 10.1038/ncomms9688.


Witt JA, Coras R, Schramm J, Becker AJ, Elger CE, Blümcke I, Helmstaedter C. Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy. J Neurol. 2015 Oct;262(10):2214-24. doi: 10.1007/s00415-015-7831-3.


Chen F, Becker AJ, Loturco JJ. Contribution of tumor heterogeneity in a new animal model of CNS tumors. Mol Cancer Res. 12(5):742-753.


Chen F, Becker AJ, Loturco JJ. Sources of CNS tumor heterogeneity. Oncosci. 1(7):482-483.


Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ. WONOEP appraisal: new genetic approaches to study epilepsy. Epilepsia. 2014 Aug;55(8):1170-86.


Cendes F, Sakamoto AC, Spreafico R, Bingaman W, Becker AJ. Epilepsies associated with hippocampal sclerosis. Acta Neuropathol. 2014 Jul;128(1):21-37.


Huberfeld G, Becker AJ. Commentary: Morris-Coole/Epilepsia prize. Epilepsia. 2014 May;55(5):640-1.


Lukasiuk K, Becker AJ. Molecular biomarkers of epileptogenesis. Neurotherapeutics. 2014 Apr;11(2):319-23.


Fuchs A, König K, Heukamp LC, Fassunke J, Kirfel J, Huss S, Becker AJ, Büttner R, Majores M. Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer. Diagn Pathol. 9:48, 2014.


Koelsche C, Sahm F, Wöhrer A, Jeibmann A, Schittenhelm J, Kohlhof P, Preusser M, Romeike B, Dohmen-Scheufler H, Hartmann C, Mittelbronn M, Becker A, von Deimling A, Capper D. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 24(3):221-229, 2014


Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun. 5:4563. doi: 10.1038/ncomms5563, 2014.


Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G; The 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS; The EPICURE Consortium, The EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy. Hum Mol Genet. 23(22):6069-6080, 2014.


Sišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, von der Kammer H, Remy S. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease. Neuron, 84(5):1023-1033, 2014.


Urbach H, Huppertz HJ, Schwarzwald R, Becker AJ, Wagner J, Bahri MD, Tschampa HJ. Is the type and extent of hippocampal sclerosis measurable on high-resolution MRI? Neuroradiology. 56(9):731-735, 2014.


Witt JA, Coras R, Schramm J, Becker AJ, Elger CE, Blümcke I, Helmstaedter C. The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy. Hippocampus. 24(4):446-454, 2014.


Japp A, Gielen GH, Becker AJ. Recent aspects of classification and epidemiology of epilepsy-associated tumors. Epilepsia. 2013 Dec;54 Suppl 9:5-11.


Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. RIM3γ and RIM4γ are key regulators of neuronal arborization. J Neurosci. 33(2):824-839, 2013.


Bien CG, Tiemeier H, Sassen R, Kuczaty S, Urbach H, von Lehe M, Becker AJ, Bast T, Herkenrath P, Karenfort M, Kruse B, Kurlemann G, Rona S, Schubert-Bast S, Vieker S, Vlaho S, Wilken B, Elger CE. Rasmussen encephalitis: Incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins. Epilepsia. 54(3):543-550, 2013.


Bien CG, Raabe AL, Schramm J, Becker A, Urbach H, Elger CE. Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009. J Neurol Neurosurg Psychiatry. 84(1):54-61, 2013.


Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, von Lehe M, Hoffmann P, Cichon S, Schoch S, Becker AJ. Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi. Neurobiol Dis. 60:115-25, 2013.


Kasperaviciute D, Catarino CB, Matarin M, Leu C, Novy J, Tostevin A, Leal B, Hessel EV, Hallmann K, Hildebrand MS, Dahl HH, Ryten M, Trabzuni D, Ramasamy A, Alhusaini S, Doherty CP, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Zumsteg D, Duncan S, Kälviäinen RK, Eriksson KJ, Kantanen AM, Pandolfo M, Gruber-Sedlmayr U, Schlachter K, Reinthaler EM, Stogmann E, Zimprich F, Théâtre E, Smith C, O’Brien TJ, Meng Tan K, Petrovski S, Robbiano A, Paravidino R, Zara F, Striano P, Sperling MR, Buono RJ, Hakonarson H, Chaves J, Costa PP, Silva BM, da Silva AM, de Graan PN, Koeleman BP, Becker A, Schoch S, von Lehe M, Reif PS, Rosenow F, Becker F, Weber Y, Lerche H, Rössler K, Buchfelder M, Hamer HM, Kobow K, Coras R, Blumcke I, Scheffer IE, Berkovic SF, Weale ME; UK Brain Expression Consortium, Delanty N, Depondt C, Cavalleri GL, Kunz WS, Sisodiya SM. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain. 136(Pt 10):3140-3150, 2013.


Koelsche C, Sahm F, Wöhrer A, Jeibmann A, Schittenhelm J, Kohlhof P, Preusser M, Romeike B, Dohmen-Scheufler H, Hartmann C, Mittelbronn M, Becker A, von Deimling A, Capper D. BRAF mutated Pleomorphic Xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 24(3):221-229, 2013 .


Krestel H, Raffel S, von Lehe M, Jagella C, Moskau-Hartmann S, Becker A, Elger CE, Seeburg PH, Nirkko A. Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy. Neurobiol Dis. 56C:66-73, 2013.


Malter MP, Tschampa HJ, Helmstaedter C, Urbach H, von Lehe M, Becker A, Clusmann H, Elger CE, Bien CG. Outcome after epilepsy surgery in patients with MRI features of bilateral ammon’s horn sclerosis. Epilepsy Res. 105(1-2):150-157, 2013.


Niehusmann P, Becker AJ, Malter MP, Raabe A, Boström A, von der Brelie C. Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas. Epilepsy Res. 107(1-2):190-194, 2013


Pernhorst K, Herms S, Hoffmann P, Cichon S, Schulz H, Sander T, Schoch S, Becker AJ, Grote A. TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue. Seizure. 22(8):675-678, 2013.


Pernhorst K, van Loo KM, von Lehe M, Priebe L, Cichon S, Herms S, Hoffmann P, Helmstaedter C, Sander T, Schoch S, Becker AJ. Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue. Brain Res. 1499:136-144, 2013.


Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F, Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. Acta Neuropathol. 125(3):351-358, 2013.


Sahm F, Bissel J, Koelsche C, Schweizer L, Capper D, Reuss D, Böhmer K, Lass U, Göck T, Kalis K, Meyer J, Habel A, Brehmer S, Mittelbronn M, Jones DT, Schittenhelm J, Urbschat S, Ketter R, Heim S, Mawrin C, Hainfellner JA, Berghoff AS, Preusser M, Becker A, Herold-Mende C, Unterberg A, Hartmann C, Kickingereder P, Collins VP, Pfister SM, von Deimling A. AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry. Acta Neuropathol. 126(5):757-762, 2013.


Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P. Albumin storage in neoplastic astroglial elements of gangliogliomas. Seizure, 22(2):144-150, 2013.


Schweizer L, Koelsche C, Sahm F, Piro RM, Capper D, Reuss DE, Pusch S, Habel A, Meyer J, Göck T, Jones DT, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler OD, Pfister SM, von Deimling A. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 125(5):651-658, 2013.


Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y. Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo. J Physiol. 2012 Nov 15;590(22):5895-905.


Kaya M, Becker AJ, Gürses C. Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia. Epilepsia. 2012 Nov;53 Suppl 6:31-6.


Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ, Schoch S. The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J Neurosci. 2012 Sep 5;32(36):12384-95.


Gousias K, Becker AJ, Simon M, Niehusmann P. Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol. 2012 Sep;109(3):545-53.


Berson A, Barbash S, Shaltiel G, Goll Y, Hanin G, Greenberg DS, Ketzef M, Becker AJ, Friedman A, Soreq H. Cholinergic-associated loss of hnRNP-A/B in Alzheimer’s disease impairs cortical splicing and cognitive function in mice. EMBO Mol Med. 2012 Aug;4(8):730-42.


van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem. 2012 May 4;287(19):15489-501.


Bien CG, Vincent A, Barnett MH, Becker AJ, Blümcke I, Graus F, Jellinger KA, Reuss DE, Ribalta T, Schlegel J, Sutton I, Lassmann H, Bauer J. Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain. 2012 May;135(Pt 5):1622-38.


Aronica E, Becker AJ, Spreafico R. Malformations of cortical development. Brain Pathol. 2012 May;22(3):380-401.


Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P. Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions. Epilepsia. 2012 Mar;53(3):539-48.


Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci USA, 108(27):11256-11261, 2011.


Becker SJ, Matusch A, Becker JS, Wu B, Palm C, Becker AJ, Salber D. Mass Spectrometric Imaging (MSI) of metals for biomedical research. Int J Mass Spectrom, 307(1-3):3-15, 2011.


Blümcke, I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Özkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R. The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia, 52(1):158-174, 2011.


Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP. Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus. J Neurosci. 31(40):14291-14295, 2011.


Ketzef M, Kahn J, Weissberg I, Becker AJ, Friedman A, Gitler D. Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. Neuroscience, 189:108-122, 2011.


Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron, 70(2):252-265, 2011.


Pernhorst K, Raabe A, Niehusmann P, van Loo KMJ, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ. Promoter variants determine GABA-homeostasis related gene transcription in human epileptic hippocampi. J Neuropathol Exp Neurol, 70(12):1080-1088, 2011.


Schijns OE, Bien CG, Majores M, von Lehe M, Urbach H, Becker A, Schramm J, Elger CE, Clusmann H. Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis. Neurosurgery, 68(1):98-106, 2011.


Schönberger A, Gembe E, Grote A, Witt JA, Elger CE, Bien CG, Urbach H, Becker AJ, Niehusmann P. Genetic analysis of tuberous-sclerosis genes 1 and 2 in non-lesional focal epilepsy. Epilepsy Behav, 21(3):233-237, 2011.


Wilcke A, Ligges C, Burkhardt J, Alexander M, Wolf C, Quente E, Ahnert P, Hoffmann P, Becker A, Müller-Myhsok B, Cichon S, Boltze J, Kirsten H. Imaging genetics of FOXP2 in dyslexia. Eur J Hum Genet, in press, 2011.


Zürner M, Mittelstaedt T, tom Dieck S, Becker AJ, Schoch S. Differential spatiotemporal expression and subcellular localization of Liprin-a proteins indicate isoform specific functions. J Comp Neurol, 519(15):3019-3039, 2011.


Grote A, Kovacs A, Clusmann H, Becker AJ, Niehusmann P. Incidental pituicytoma after accidental head trauma – case report and review of literature. Clin Neuropathol, 29(3):127-33, 2010.


Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A, Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker AJ, De Jonghe P, Lerche H. Molecular correlates of age-dependent seizures in inherited neonatal-infantile epilepsy. Brain, 133:1403-1414, 2010.


Niehusmann P, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ. Presence of human herpes virus-6 DNA in temporal lobe epilepsy brain tissue of patients with history of encephalitis but not other pathologies. Epilepsia, 51(12):2478-2483, 2010.


Bien CG, Szinay M, Wagner J, Clusmann H, Becker AJ, Urbach H. Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies. Arch Neurol, 66(12):1491-1499, 2009.


Blümcke I, Kistner I, Clusmann H, Schramm J, Becker AJ, Elger C, Bien CG, Merschhemke M, Meencke HJ, Lehmann T, Buchfelder M, Weigel D, Buslei R, Stefan H, Pauli E, Hildebrandt M. Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies. Acta Neuropathol, 117(5):535-544, 2009.


Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J, Urbach H. Simple and Complex Dysembryoplastic Neuroepithelial Tumors (DNT): clinical profile, MRI and histopathology. Neuroradiology, 51(7):433-443, 2009.


ElSharawy A, Hundrieser B, Brosch M, Wittig M, Huse K, Platzer M, Becker AJ, Simon M, Rosenstiel P, Schreiber S, Krawczak M, Hampe J. Systematic evaluation of the effect of common SNPs on pre-mRNA splicing. Hum Mutat, 30(4):625-632, 2009.


Faber-Zuschratter H, Hüttmann K, Steinhäuser C, Becker A, Schramm J, Okafo U, Shanley D, Yilmazer-Hanke DM. Ultrastructural and functional characterization of satellitosis in the human lateral amygdala associated with Ammon’s horn sclerosis. Acta Neuropathol, 117(5):545-555, 2009.


Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A. Hamartin variants frequent in focal dysplasias and cortical tubers reveal reduced tuberin binding and aberrant subcellular distribution in vitro. J Neuropathol Exp Neurol, 68(10):1136-1146, 2009.


Marcelin B, Chauvière L, Becker A, Migliore M, Esclapez M, Bernard C. h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy. Neurobiol Dis, 33(3):436-447, 2009.


Mittelsteadt T, Seifert G, Alvárez-Barón E, Steinhäuser C, Becker AJ, Schoch S. Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain. J Comp Neurol, 512(4):514-528, 2009


Schönberger A, Niehusmann P, Urbach H, Majores M, Grote A, Holthausen H, Blümcke I, Deckert M, Becker AJ. Increased Frequency of Distinct TSC2 Allelic Variants in FCDs with Balloon Cells and Mineralization. Neuropathology, 5:559-565, 2009.


Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, Dornmair K, Wiendl H. CD8+ T cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain, 132(5):1236-1246, 2009.


Battaglia G, Becker AJ, LoTurco J, Represa A, Baraban SC, Roper SN, Vezzani A. Basic Mechanisms in MCD in Animal Models. Epileptic Disorders, 11:802-808, 2009.


Snoei J, Urbach H, Engels G, Fassunke J, von Lehe M, Becker AJ, Majores M. Genetic alterations of protein-o-mannosyltransferase-1 in glioneuronal and glial brain tumors with subarachnoid spread. Neuropathology. 29(2):116-124, 2009.


Alvarez-Barón E, Bien CG, Schramm J, Elger CE, Becker AJ, Schoch S. Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. Epilepsy Res, 80(1):93-97, 2008.


Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen CC, Campbell KP, Schoch S, Yaari Y, Beck H. Transcriptional upregulation of CaV3.2 mediates epileptogenesis in the pilocarpine epilepsy model. J Neurosci, 28(49):13341-13353, 2008.


Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ. Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain, 131:3034-3050, 2008.


Hoischen A, Ehrler M, Fassunke J, Simon M, Baudis M, Landwehr C, Raldwimmer B, Lichter B, Schramm J, Becker AJ, Weber RG. Comprehensive characterization of genomic aberrations in gangliogliomas by comparative genomic hybridization (CGH), array-based CGH and interphase-FISH. Brain Pathol, 18(3):326-337, 2008


Majores M, von Lehe M, Fassunke J, Schramm J, Becker AJ, Simon M. Tumor recurrence and malignant progression of gangliogliomas. Cancer, 113(12):3355-3363, 2008.


Aronica E, Boer K, Becker A, Redeker S, Spliet WGM, van Rijen PC, Wittink F, Breit T, Wadman WJ, Gorter JA. Gene expression profile analysis of epilepsy-associated gangliogliomas. Neuroscience, 151(1): 272-292, 2007.


Bien CG, Urbach H, Schramm J, Soeder BM, Becker AJ, Voltz R, Vincent A, Elger CE. Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy. Neurology, 18;69(12):1236-1244, 2007.


Blümcke I, Pauli E, Clusmann H, Schramm J, Becker A, Elger C, Merschhemke M, Meencke HJ, Lehmann T, von Deimling A, Scheiwe C, Zentner J, Volk B, Romstock J, Stefan H, Hildebrandt M. A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol, 113(3):235-244, 2007.


Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Chen J, Reitze M, Becker AJ, Schoch S, Beck H. Loss of metabotropic glutamate receptor-dependent LTD via downregulation of mGluR5 following status epilepticus. J Neurosci, 27(29):7696-7704, 2007.


Kral T, von Lehe M, Podlogar M, Clusmann H, Sussmann P, Kurthen M, Becker A, Urbach H, Schramm J. Focal cortical dysplasia: Long-term seizure outcome after surgical treatment. J Neurol Neurosurg Psychiatry, 78(8): 853-856, 2007.


Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ. Functional role of mGluR1 and mGluR4 in pilocarpine induced temporal lobe epilepsy. Neurobiol Dis, 26(3), 623-633, 2007.


Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, Schoch S, Becker AJ. Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol, 17(2):165-173, 2007.


Schick V, Majores M, Koch A, Elger CE, Schramm J, Urbach H, Becker AJ. Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy associated glioneuronal lesions. Epilepsia, 48 Suppl 5:65-73, 2007.


Schick V, Majores M, Fassunke J, Engels G, Simon M, Elger CE, Becker AJ. Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions. Neuropathol Appl Neurobiol, 33(2):152-162, 2007


Stenzel W, Franitza M, Becker AJ, Montesinos-Rongen M, Lohr M, Lee JY, Rohn G, Miletic H, Deckert M. A 30-year-old patient with tuberous sclerosis. Brain Pathol, 17(3):333-334, 2007.


Urbach H, Binder D, von Lehe M, Podlogar M, Bien CG, Becker A, Schramm J, Kral T, Clusmann H. Correlation of MRI and histopathology in epileptogenic parietal and occipital lobe lesions. Seizure, 16(7):608-614, 2007.


Stuer C, Vilz B, Majores M, Becker A, Schramm J, Simon M. Frequent recurrence and progression in pilocytic astrocytoma in adults. Cancer, 110(12):2799-2808, 2007.


Yilmazer-Hanke DM, Faber-Zuschratter H, Blümcke I, Bickel M, Becker A, Mawrin C, Schramm J. Axo-somatic inhibition of projection neurons in the lateral nucleus of amygdala in human temporal lobe epilepsy: an ultrastructural study. Exp Brain Res, 177:384-399, 2007.


Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G. Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas. Oncogene, 26(7):1088-1097, 2007.


Majores M, Lie A, Schoch S, Becker AJ. Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia, 48 Suppl 2:4-12, 2007.


Baars C, Löscher W, Leeb T, Becker A, Potschka H. Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy. Eur J Pharmacol, 550:54-61, 2006.


Dupont P, Van Paesschen W, Palmini A, Ambayi R, Van Loon J, Goffin J, Weckhuysen S, Sunaert S, Thomas B, Demaerel P, Sciot R, Becker AJ, H. Vanbilloen H, Mortelmans L, Van Laere K. Ictal perfusion patterns associated with single MR-visible focal dysplastic lesions: implications for the non-invasive delineation of the epileptogenic zone. Epilepsia, 47(9):1550-1557, 2006.


ElSharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M, Becker A, Nürnberg P, Schreiber S, Hampe J. SNPSplicer – Systematic analysis of SNP-dependent splicing in genotyped cDNAs. Hum Mutat, 27:1129-1134, 2006.


Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Pääbo S, Khaitovich P. Systematic analysis of gene expression in human brains before and after death. Genome Biology, 6(13):R112, 2006.


Hamacher M, Apweiler R, Arnold G, Becker A, Bluggel M, Carrette O, Colvis C, Dunn MJ, Frohlich T, Fountoulakis M, van Hall A, Herberg F, Ji J, Kretzschmar H, Lewczuk P, Lubec G, Marcus K, Martens L, Palacios Bustamante N, Park YM, Pennington SR, Robben J, Stuhler K, Reidegeld KA, Riederer P, Rossier J, Sanchez JC, Schrader M, Stephan C, Tagle D, Thiele H, Wang J, Wiltfang J, Yoo JS, Zhang C, Klose J, Meyer HE. HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Proteomics, 6(18):4890-4898, 2006.


Rüschenschmidt C, Chen J, Becker A, Riazanski V, Beck H. Functional properties and oxidative modulation of A-type K+ currents in hippocampal granule cells of control and chronically epileptic rats. Eur J Neurosci, 23(3):675-685, 2006.


Schick V, Majores M, Engels G, Spitoni S, Koch A, Elger CE, Simon M, Knobbe C, Blümcke I, Becker AJ. Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias. Acta Neuropathol, 112(6):715-725, 2006.


Becker AJ. Neuropathology and classification of cortical malformations – where do they develop? Epilepsia, 47:949-951, 2006.


Becker AJ, Blümcke I, Urbach H, Hans V, Majores M. Molecular neuropathology of epilepsy-associated glioneuronal malformations. J Neuropathol Exp Neurol, 65(2):99-108, 2006.


Crino PB, Becker AJ. Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions. Epilepsia, 47(10):1608-1616, 2006.


Majores M, Schick V, Engels G, Fassunke J, Elger CE, Schramm J, Blümcke I, Becker AJ. Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions. Acta Neuropathol. 2005 Dec;110(6):537-46.


Chen J, Larionov S, Hoerold N, Ullmann C, Elger CE, Schramm J, Becker AJ. Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. Neurosci Lett, 375(3):192-197, 2005.


Fell J, Köhling R, Grunwald T, Klaver P, Dietl T, Schaller C, Becker A, Elger CE, Fernandez G. Phase-locking characteristics of limbic P3 responses in hippocampal sclerosis. Neuroimage, 24(4):980-989, 2005.


Majores M, Blümcke I, Urbach H, Meroni A, Hans V, Holthausen H, Elger CE, Schramm J, Galli C, Spreafico R, Wiestler OD, Becker AJ. Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells. J Neuropathol Exp Neurol, 64(7):629-637, 2005.


Majores M, Schick V, Engels G, Fassunke J, Elger CE, Schramm J, Blümcke I, Becker AJ. Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy associated glioneuronal lesions. Acta Neuropathol, 110:537-546, 2005.


Fassunke J, Blümcke I, Lahl R, Elger CE, Schramm J, Merkelbach-Bruse S, Mathiak M, Wiestler OD, Becker AJ. Analysis of chromosomal instability in focal cortical dysplasia of Taylor’s balloon cell type. Acta Neuropathol. 2004 Aug;108(2):129-34.


Bernard C, Anderson A, Becker A, Poolos N, Beck H, Johnston D. Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305(5683):532-535, 2004.


Fassunke J, Blümcke I, Lahl R, Elger CE, Schramm J, Merkelbach-Bruse S, Mathiak M, Wiestler OD, Becker AJ. Chromosomal instability at loci other than TSC1 is rare in focal cortical dysplasia of Taylor’s balloon cell type. Acta Neuropathol, 108(2):129-134, 2004.


Fassunke J, Majores M, Ullmann C, Elger CE, Schramm J, Wiestler OD, Becker AJ. In situ-RT and immuno-laser microdissection for mRNA analysis of individual cells isolated from epilepsy associated glioneuronal tumors. Lab Invest, 84(11): 1520-1525, 2004.


Fauser S, Becker A, Schulze-Bonhage A, Hildebrandt M, Tuxhorn I, Pannek HW, Lahl R, Schramm J, Blümcke I. CD34-immunoreactive balloon cells in cortical malformations. Acta Neuropathol, 108(4): 272-278, 2004.


Kam R, Chen J, Blümcke I, Normann S, Fassunke J, Elger CE, Schramm J, Wiestler OD, Becker AJ. The reelin pathway components disabled-1 and p35 in gangliogliomas – a mutation and expression analysis. Neuropathol Appl Neurobiol, 30: 225-232, 2004.


Rudlowski C, Moser M, Becker AJ, Rath W, Büttner R, Schröder W, Schurmann A. GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology, 66 (5):404-410, 2004.


Volk HA, Burkhardt K, Potschka H, Chen J, Becker A, Löscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123(3):751-759, 2004.


Majores M, Eils J, Wiestler OD, Becker AJ. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res, 60:173-178, 2004.


Schulte JH, Pitsch J, Becker AJ. Functional genomics and target gene validation in experimental and human disease. Drug Discovery Today: Technologies, 1(2):105-111, 2004.


Becker AJ, Chen J, Zien A, Sochivko D, Normann S, Schramm J, Elger CE, Wiestler OD, Blümcke I. Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci 18(10):2792-2802, 2003.


Ellerkmann RE, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 119:323-333, 2003.


Kulla A, Burkhardt K, Meyer-Puttlitz B, Teesalu T, Asser T, Wiestler OD, Becker AJ. Analysis of the TP53 gene in laser microdissected glioblastoma vasculature. Acta Neuopathol, 105(4):328-332, 2003.


Rudlowski C, Becker AJ, Schröder W, Rath W, Büttner R, Moser M. GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer. Am J Clin Pathol. 120(5):691-698, 2003.


Sochivko D, Chen J, Becker A, Beck H. Blocker resistant Ca2+ currents in rat CA1 hippocampal pyramidal neurons. Neuroscience 116:629–638, 2003.


Urbach H, Blümcke I, Becker A, Solymosi L. Störungen der kortikalen Entwicklung: Bildgebung und Klassifizierung. Klin Neuroradiol 13:163-172, 2003.


Becker AJ, Chen J, Paus S, Normann S, Beck H, Elger CE, Wiestler OD, Blümcke I. Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation. Neuroreport 13:1327-1333, 2002.


Becker AJ, Klein H, Baden T, Aigner L, Normann S, Elger CE, Schramm J, Wiestler OD, Blümcke I. Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. Acta Neuropathol 104(4):403-408, 2002.


Becker AJ, Urbach H, Scheffler B, Baden T, Normann S, Lahl R, Pannek HW, Tuxhorn I, Elger CE, Schramm J, Wiestler OD, Blümcke I. Focal cortical dysplasia of Taylor’s balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann Neurol 52:29-37, 2002.


Su H, Sochivko D, Becker A, Chen J, Jiang Y, Yaari Y, Beck H. Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J Neurosci 22:3645-3655, 2002.


Varlamov DA, Kudin AP, Vielhaber S, Schröder R, Sassen R, Becker A, Kunz D, Haug K, Rebstock J, Heils A, Elger CE, Kunz WS. Metabolic consequences of a novel missense mutation of the mtDNA CO I gene. Hum Mol Genet 11:1797-1805, 2002.


Becker AJ, Wiestler OD, Blümcke I. Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage. Prog Brain Res 135:161-173, 2002.


Becker AJ, Löbach M, Klein H, Normann S, Nöthen MM, von Deimling A, Mizuguchi M, Elger CE, Schramm J, Wiestler OD, Blümcke I. Mutational analysis of TSC1 and TSC2 genes in gangliogliomas. Neuropathol Appl Neurobiol, 27:105-114, 2001.


Blümcke I, Becker AJ, Normann S, Hans V, Riederer BM, Krajewski S, Wiestler OD, Reifenberger G. Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells. J Neuropathol Exp Neurol 60:984-993, 2001.


Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, Becker AJ. Activity-induced expression of common reference genes in individual CNS neurons. Lab Invest 81(6):913-916, 2001.


Dettmeyer R, Driever F, Becker A, Wiestler OD, Madea B. Fatal myeloencephalopathy due to accidental intrathecal vincristin administration – a report of two cases. J Forensic Sci 122 (1):60-64, 2001.


Riazanski V, Becker A, Chen J, Sochivko D, Lie A, Wiestler OD, Elger CE, Beck H. Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J Physiol 537:391-406, 2001.


Rudlowski C, Rath W, Becker AJ, Wiestler OD, Büttner R. Trastuzumab and breast cancer. New Engl J Med 345 (13):997-998, 2001.


Blümcke I, Becker A, Klein C, Scheiwe C, Lie AA, Beck H, Waha A, Friedel M, Kuhn R, Emson P, Elger C, Wiestler OD. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J Neuropathol Exp Neurol 59:1-10, 2000.


Busjahn A, Li GH, Faulhaber HD, Rosenthal M, Becker A, Jeschke E, Schuster H, Timmermann B, Hoehe MR, Luft FC. beta-2 Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size in Normal Twins. Hypertension 35:555-560, 2000.


Lie AA, Becker A, Behle K, Beck H, Malitschek B, Conn PJ, Kuhn R, Nitsch R, Plaschke M, Schramm J, Elger CE, Wiestler OD, Blümcke I. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol 47:26-35, 2000.


Becker AJ, Gillardon F, Blümcke I, Langendörfer D, Beck H, Wiestler OD. Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Res Mol Brain Res 67:172-176, 1999.


Becker AJ, Busjahn A, Faulhaber HD, Bähring S, Robertson J, Schuster H, Luft FC. Twin zygosity. Automated determination with microsatellites. J Reprod Med 42:260-266, 1997.


Busjahn A, Knoblauch H, Knoblauch M, Bohlender J, Menz M, Faulhaber HD, Becker A, Schuster H, Luft FC. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms, plasma levels, cardiac dimensions. A twin study. Hypertension 29:165-170, 1997.


Buchbeiträge

Becker AJ. Epilepsy-associated gangliogliomas: identification of genes with altered expression. Tumors of the Central Nervous System. Volume 5, Hayat MA (ed.). 2012, Volume 5, Part 5, 267-273 Springer Press.


Becker AJ, Wiestler OD, Figarella-Branger D, Blümcke I. Ganglioglioma and Gangliocytoma. In: WHO Classification of Tumours of the Central Nervous System, Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (eds.), pp. 103-105, IARC: Lyon, 2007.


Nakazato Y, Figarella-Branger D, Becker AJ, Scheithauer BW, Rosenblum MK. Papillary glioneuronal tumour. In: WHO Classification of Tumours of the Central Nervous System, Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (eds.), pp. 103-105, IARC: Lyon, 2007.


Seifert G, Becker AJ, Steinhäuser C. Combining patch-clamp techniques with RT-PCR. In: Advanced techniques for patch clamp analysis. Walz W, Boulton A, Baker G, eds. Humana Press, 301-330, 2002.