Publications


Bohmbach K, Schwarz MK, Schoch S, Henneberger C

The structural and functional evidence for vesicular release from astrocytes in situ

Brain Research Bulletin 17 (2017)


Tognatta R, Sun W, Goebbels S, Nave K-A, Nishiyama A, Schoch S, Dimou L, Dietrich D

Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates

Glia 65 (2017)


Robens BK, Gembé E, Fassunke J, Becker AJ, Schoch S, Grote A

Abundance of LRP12 C-rs9694676 allelic promoter variant in epilepsy-associated gangliogliomas

Life Sciences 155 (2016)


Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H.

Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus

Neuron 90 (2016)


LaConte LEW, Chavan V, Liang C, Willis J, Schönhense E-M, Schoch S, Mukherjee K

CASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner

Cellular and Molecular Life Sciences 73 (2016)


Bungenberg J, Surano N, Grote A, Surges R, Pernhorst K, Hofmann A, Schoch S, Helmstaedter C, Becker AJ

Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance

Neurobiology of Disease 86 (2016)


Woitecki AMH, Müller JA, van Loo KMJ, Sowade RF, Becker AJ, Schoch S

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration

Journal of Neuroscience 36 (2016)


Grote A, Robens BK, Blumcke I, Becker AJ, Schoch S, Gembé E

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization.

Neurobiology of Disease 86 (2016)


Robens BK, Grote A, Pitsch J, Schoch S, Cardoso C, Becker AJ

Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice

Neurobiology of Disease 95 (2016)


Ü Basmanav FB, Cau L, Tafazzoli A, Méchin M-C, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJ, Oprisoreanu AM, Wehner M, Thiele H, Altmüller J, Nürnberg P, Swan D, Houniet D, Büchner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

American Journal of human genetics 99 (2016)


Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS.

Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy

Acta Neuropathologica 132 (2016)


Sun W, Matthews EA, Nicolas V, Schoch S, Dietrich D

NG2 glial cells integrate synaptic input in global and dendritic calcium signals

eLife 5 (2016)


Schoch S., Müller J.A., Oprişoreanu A.-M.

Liprins, ELKS, and RIM-BP Proteins.

Reference Module in Biomedical Research: Elsevier (2015)


Petretto E, Behmoaras J, Bottolo L, Krishnan M, Pernhorst K, Speed D, Chadeau-Hyam M, Srivastava PK, Deplano S, Hajji N, Dabrowska A, Langley SR, Torlai Triglia E, De T, Mattheisen M, Niehusmann P, Marson A, Pirmohamed M, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffee A, Palotie A, Cichon S, Schoch S, Becker A, Johnson MR

Sestrin 3 genetically regulates a disease associated transcriptional network in human epilepsy.

Nature Communications 6 (2015)


Royeck M, Kelly T, Opitz T, Otte D-M, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H.

Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus

Journal of Neuroscience 35 (2015)


Lal D, Steinbrücker S, Schubert J, Sander T, Becker F, Weber Y, Lerche H, Thiele H, Krause R, Lehesjoki A-E, Nürnberg P, Palotie A, Neubauer BA, Muhle H, Stephani U, Helbig I, Becker AJ, Schoch S, Hansen J, Thomas Dorn T, Hohl C, Lüscher N, Epicure consortium, EuroEPINOMICS-CoGIE consortium, von Spiczakj S, Lemkeb RJ

Investigation of GRIN2A in common epilepsy phenotypes

Epilepsy Research 115 (2015)


Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S

Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit

Neuron 86 (2015)


Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T

Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones

Proc. Natl. Acad. Sci. USA 112 (2015)


Dannenberg H, Pabst M, Braganza O, Schoch S, Niediek J, Bayraktar M, Mormann F, Beck H

Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks

Journal of Neuroscience 35 (2015)



Michel K, Müller JA, Oprisoreanu A-M, Schoch S

The presynaptic active zone: A dynamic scaffold that regulates synaptic efficacy

Experimental Cell Research 335 (2015)


van Loo KMJ, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Susanne Schoch, Albert J Becker

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1

Nature Communications 6 (2015)


Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G; The 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS; The EPICURE Consortium, The EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA; The 16p11 2 European Consortium

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.

Human Molecular Genetics 23:6069–6080 (2014)


Kulbida R., Wang Y., Mandelkow E.-M., Schoch S., Becker A.J., van Loo KMJ.

In vivo bioluminescence imaging reveals sustained epileptogenic Ca2+-channel upregulation in hippocampi after status epilepticus.

Brain Structure & Function 1-7 (2014)


Šišková Z., Justus D., Kaneko H., Friedrichs D., Henneberg N., Beutel T., Pitsch J., Schoch S., Becker A., von der Kammer H. and Remy S.

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer’s disease.

Neuron 84:1023–1033 (2014)


International League Against Epilepsy Consortium on Complex Epilepsies. Electronic address: epilepsy-austin@unimelb.edu.au

Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.

Lancet Neurol 13:893–903 (2014)


Esposito L, Drexler, JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten C, Schoch S, Elger CE, Becker AJ, Niehusmann P

Large scale analysis of viral nucleic acid spectrum in temporal lobe epilspy biopsies.

Epilepsia 56 (2014)


Weber N., Vieweg L., Henze F., Oprisoreanu A.-M., Solinski H.J., Breit A., Fecher-Trost C., Schalkowsky P., Wilhelm B., Wennemuth G., Schoch S., Gudermann T., Boekhoff I

RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

J Mol Cell Biol 6:434–437 (2014)


Basmanav FB, Oprisoreanu AM, Pasternack SM, Thiele H, Fritz G, Wenzel J, Größer L, Wehner M, Wolf S, Fagerberg C, Bygum A, Altmüller J, Rütten A, Parmentier L, El Shabrawi-Caelen L, Hafner C, Nürnberg P, Kruse R, Schoch S, Hanneken S, Betz RC

Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease

American Journal of Human Genetics 94(1), 135-143 (2014)


Kasperavičiūtė D, Catarino CB, Matari M, Costin Leu, Ph.D., Jan Novy, M.D., Anna Tostevin, M.Sc., BaÅLrbara G. Leal, M.Sc., Ellen V.S. Hessel, Ph.D., Kerstin Hallmann, M.Sc., Mina Ryten, Ph.D., Da

Genome-wide association study implicates SCN1A in mesial temporal lobe epilepsy with hippocampal sclerosis.

Brain 136 (Pt 10), 3140-50 (2013)


Grimminger T., Pernhorst K., Surges R., Niehusmann P., Priebe L., von Lehe M., Hoffmann P., Cichon S., Schoch S*., Becker A.J. * (*equal contribution)

Levetiracetam resistance: synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.

Neurobiol Dis 60C, 115-125 (2013)


Alvarez-Baron E., Michel K., Mittelstaedt T., Opitz T., Schmitz F., Beck H., Dietrich D., Becker A.J., Schoch S.

RIM3γ and RIM4γ are key regulators of neuronal arborization.

J.Neurosci 33, 824-839 (2013)


Fernández-Busnadiego R., Asano S., Sakata E., Oprisoreanu A.M., Döngi M., Kochovski Z., Zürner M., Stein V., Schoch S., Baumeister W., Lučić V.

Structural mechanism of synaptic vesicle priming by RIM1α.

J Cell Biol. 201, 725-40 (2013)


Pernhorst K., van Loo K.M.J., von Lehe M., Priebe L., Cichon S., Helmstaedter C., Sander T., Schoch S., Becker A.J.

The rs6295 promoter variant of the serotonin type 1A receptor alters its mRNA expression in human brain tissue.

Brain Res. 1499, 136-44 (2013)


Pernhorst K., Herms S., Hoffmann P., Cichon S., Schulz H., Sander T., Schoch S., Becker A.J., Grote A.

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue.

Seizure 22, 675-678 (2013)



Hildenbrand, S., Schoch, S., von Lehe, M., Surges, R. & Muller, C.E.

Tritium-Labeled Brivaracetam with High Specific Activity: Preparation, Characterization and Application in Human Brain Samples.

ChemMedChem 7, 1369-74 (2012)


Pitsch, J., Opitz, T., Borm, V., Woitecki, A., Staniek, M., Beck, H., Becker, A.J. & Schoch, S.

The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus.

J Neurosci 32, 12384-12395 (2012)


van Loo, K.M., Schaub, C., Pernhorst, K., Yaari, Y., Beck, H., Schoch, S. & Becker, A.J.

Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST).

J Biol Chem 287, 15489-15501 (2012)


Erdmann, E., Rupprecht, V., Matthews, E., Kukley, M., Schoch, S. & Dietrich, D.

Depression of Release by mGluR8 Alters Ca2+ Dependence of Release Machinery.

Cereb Cortex 22, 1498-1509 (2012)


Helmstaedter, C., Mihov, Y., Toliat, M.R., Thiele, H., Nuernberg, P., Schoch, S., Surges, R., Elger, C.E., Kunz, W.S. & Hurlemann, R.

Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam.

Epilepsia 54, 36-44 (2012)


Surges R., Schoch S., Elger C.E.

Synaptisches Vesikelprotein 2A: Beteiligung an epilepsieassoziierten Prozessen und Interaktionen mit Antikonvulsiva.

Zeitschrift für Epileptlogie. Epub 12.06.2012 (2012)


Zurner, M., Mittelstaedt, T., tom Dieck, S., Becker, A. & Schoch, S.

Analyses of the spatiotemporal expression and subcellular localization of liprin-alpha proteins.

J Comp Neurol 519, 3019-3039 (2011)


Pernhorst, K., Raabe, A., Niehusmann, P., van Loo, K.M., Grote, A., Hoffmann, P., Cichon, S., Sander, T., Schoch, S. & Becker, A.J.

Promoter variants determine gamma-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi.

J Neuropathol Exp Neurol 70, 1080-1088 (2011)


Niehusmann, P., Mittelstaedt, T., Bien, C.G., Drexler, J.F., Grote, A., Schoch, S. & Becker, A.J.

Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis.

Epilepsia 51, 2478-2483 (2010)


Mittelstaedt, T., Alvarez-Baron, E. & Schoch, S.

RIM proteins and their role in synapse function.

Biol Chem 391, 599-606 (2010)


Mittelsteadt, T., Seifert, G., Alvarez-Baron, E., Steinhauser, C., Becker, A.J. & Schoch, S.

Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain.

J Comp Neurol 512, 514-528 (2009)


Schoch S., Zürner M., Mittelstaedt, T.

ERCs, Liprins and RIM-BPs.

Squire LR (ed.) Encyclopedia of Neuroscience 2009, volume 5, 487-493. Oxford: Academic Press. (2009)


Lugnier, C., Majores, M., Fassunke, J., Pernhorst, K., Niehusmann, P., Simon, M., Nellist, M., Schoch, S. & Becker, A.

Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro.

J Neuropathol Exp Neurol 68, 1136-1146 (2009)



Fassunke, J., Majores, M., Tresch, A., Niehusmann, P., Grote, A., Schoch, S. & Becker, A.J.

Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors.

Brain 131, 3034-3050 (2008)


Alvarez-Baron, E., Bien, C.G., Schramm, J., Elger, C.E., Becker, A.J. & Schoch, S.

Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis.

Epilepsy Res 80, 93-97 (2008)


Mittelstaedt, T., Alvarez-Barón, E., Schoch, S.

The Cytomatrix of presynaptic active zones: Molecular organization and function.

Neuroforum 3/2008 (2008)


Becker, A.J., Pitsch, J., Sochivko, D., Opitz, T., Staniek, M., Chen, C.C., Campbell, K.P., Schoch, S., Yaari, Y. & Beck, H.

Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.

J Neurosci 28, 13341-13353 (2008)


Atasoy, D., Schoch, S., Ho, A., Nadasy, K.A., Liu, X., Zhang, W., Mukherjee, K., Nosyreva, E.D., Fernandez-Chacon, R., Missler, M., Kavalali, E.T. & Sudhof, T.C.

Deletion of CASK in mice is lethal and impairs synaptic function.

Proc Natl Acad Sci U S A 104, 2525-2530 (2007)


Schick, V., Majores, M., Engels, G., Hartmann, W., Elger, C.E., Schramm, J., Schoch, S. & Becker, A.J.

Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells.

Brain Pathol 17, 165-173 (2007)


Pitsch, J., Schoch, S., Gueler, N., Flor, P.J., van der Putten, H. & Becker, A.J.

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.

Neurobiol Dis 26, 623-633 (2007)


Kirschstein, T., Bauer, M., Muller, L., Ruschenschmidt, C., Reitze, M., Becker, A.J., Schoch, S. & Beck, H.

Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.

J Neurosci 27, 7696-7704 (2007)


Majores, M., Schoch, S., Lie, A. & Becker, A.J.

Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue.

Epilepsia 48 Suppl 2, 4-12 (2007)


Mittelstaedt, T. & Schoch, S.

Structure and evolution of RIM-BP genes: identification of a novel family member.

Gene 403, 70-79 (2007)


Schoch, S. & Gundelfinger, E.D.

Molecular organization of the presynaptic active zone.

Cell Tissue Res 326, 379-391 (2006)


Schoch, S., Mittelstaedt, T., Kaeser, P.S., Padgett, D., Feldmann, N., Chevaleyre, V., Castillo, P.E., Hammer, R.E., Han, W., Schmitz, F., Lin, W. & Sudhof, T.C.

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

EMBO J 25, 5852-5863 (2006)


Huang, Y.Y., Zakharenko, S.S., Schoch, S., Kaeser, P.S., Janz, R., Sudhof, T.C., Siegelbaum, S.A. & Kandel, E.R.

Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.

Proc Natl Acad Sci U S A 102, 9365-9370 (2005)


Calakos, N., Schoch, S., Sudhof, T.C. & Malenka, R.C.

Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.

Neuron 42, 889-896 (2004)


Deak, F., Schoch, S., Liu, X., Sudhof, T.C. & Kavalali, E.T.

Synaptobrevin is essential for fast synaptic-vesicle endocytosis.

Nat Cell Biol 6, 1102-1108 (2004)


Powell, C.M., Schoch, S., Monteggia, L., Barrot, M., Matos, M.F., Feldmann, N., Sudhof, T.C. & Nestler, E.J.

The presynaptic active zone protein RIM1alpha is critical for normal learning and memory.

Neuron 42, 143-153 (2004)


Lonart, G., Schoch, S., Kaeser, P.S., Larkin, C.J., Sudhof, T.C. & Linden, D.J.

Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses.

Cell 115, 49-60 (2003)


Schoch, S. *, Castillo, P.E. *, Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R.C. & Sudhof, T.C.

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.

Nature 415, 321-326 (2002)


Castillo, P.E. *, Schoch, S. *, Schmitz, F., Sudhof, T.C. & Malenka, R.C.

RIM1alpha is required for presynaptic long-term potentiation.

Nature 415, 327-330 (2002)


Schoch, S., Cibelli, G., Magin, A., Steinmuller, L. & Thiel, G.

Modular structure of cAMP response element binding protein 2 (CREB2).

Neurochem Int 38, 601-608 (2001)


Schoch, S., Deak, F., Konigstorfer, A., Mozhayeva, M., Sara, Y., Sudhof, T.C. & Kavalali, E.T.

SNARE function analyzed in synaptobrevin/VAMP knockout mice.

Science 294, 1117-1122 (2001)



Cibelli, G., Schoch, S. & Thiel, G.

Nuclear targeting of cAMP response element binding protein 2 (CREB2).

Eur J Cell Biol 78, 642-649 (1999)


Cibelli, G. *, Schoch, S. *, Pajunk, H., Brand, I.A. & Thiel, G.

A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element.

Eur J Biochem 237, 311-317 (1996)


Cibelli, G., Jungling, S., Schoch, S., Gerdes, H.H. & Thiel, G.

Identification of a functional cAMP response element in the secretogranin II gene.

Eur J Biochem 236, 171-179 (1996)


Schoch, S., Cibelli, G. & Thiel, G.

Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism.

J Biol Chem 271, 3317-3323 (1996)


Thiel, G., Petersohn, D. & Schoch, S.

pHIVTATA-CAT, a versatile vector to study transcriptional regulatory elements in mammalian cells.

Gene 168, 173-176 (1996)


Petersohn, D., Schoch, S., Brinkmann, D.R. & Thiel, G.

The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2.

J Biol Chem 270, 24361-24369 (1995)


Thiel, G., Schoch, S. & Petersohn, D.

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

J Biol Chem 269, 15294-15301 (1994)