Publications


Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ.

WONOEP appraisal: New genetic approaches to study epilepsy.

Epilepsia. 55(8):1170-86 (2014)


Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M, Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J, Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G; The 16p11.2 European Consortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, Beckmann JS; The EPICURE Consortium, The EuroEPINOMICS Consortium, Sander T, Jacquemont S, Reymond A, Zimprich F, Neubauer BA.

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.

Hum Mol Genet. 15;23(22):6069-80 (2014)



Chen F, Becker AJ, Loturco JJ.

Contribution of tumor heterogeneity in a new animal model of CNS tumors.

Mol Cancer Res. 12(5):742-753 (2014)


Cendes F, Sakamoto AC, Spreafico R, Bingaman W, Becker AJ.

Epilepsies associated with hippocampal sclerosis.

Acta Neuropathol. 128(1):21-37 (2014)


Urbach H, Huppertz HJ, Schwarzwald R, Becker AJ, Wagner J, Bahri MD, Tschampa HJ.

Is the type and extent of hippocampal sclerosis measurable on high-resolution MRI?

Neuroradiology. 56(9):731-5 (2014)


Lukasiuk K, Becker AJ.

Molecular biomarkers of epileptogenesis.

Neurotherapeutics. 11(2):319-323 (2014)


Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM.

Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.

Brain Struct Funct. in press (2014)


Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N.

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

Nat Commun. 1;5:4563 (2014)


Witt JA, Coras R, Schramm J, Becker AJ, Elger CE, Blümcke I, Helmstaedter C.

The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy.

Hippocampus. 24(4):446-454 (2014)


Fuchs A, König K, Heukamp LC, Fassunke J, Kirfel J, Huss S, Becker AJ, Büttner R, Majores M.

Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer.

Diagn Pathol. 9:48 (2014)


Krestel H, Raffel S, von Lehe M, Jagella C, Moskau-Hartmann S, Becker A, Elger CE, Seeburg PH, Nirkko A.

Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy.

Neurobiol Dis. 56C:66-73 (2013)


Kasperaviciute D, Catarino CB, Matarin M, Leu C, Novy J, Tostevin A, Leal B, Hessel EV, Hallmann K, Hildebrand MS, Dahl HH, Ryten M, Trabzuni D, Ramasamy A, Alhusaini S, Doherty CP, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Zumsteg D, Duncan S, Kälviäinen RK, Eriksson KJ, Kantanen AM, Pandolfo M, Gruber-Sedlmayr U, Schlachter K, Reinthaler EM, Stogmann E, Zimprich F, Théâtre E, Smith C, O'Brien TJ, Meng Tan K, Petrovski S, Robbiano A, Paravidino R, Zara F, Striano P, Sperling MR, Buono RJ, Hakonarson H, Chaves J, Costa PP, Silva BM, da Silva AM, de Graan PN, Koeleman BP, Becker A, Schoch

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.

Brain. 136(Pt 10):3140-3150 (2013)


Niehusmann P, Becker AJ, Malter MP, Raabe A, Boström A, von der Brelie C.

Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas.

Epilepsy Res. 2013 Aug 5 (2013)


Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, von Lehe M, Hoffmann P, Cichon S, Schoch S, Becker AJ.

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi.

Neurobiol Dis. 2013 Sep 7;60C:115-125. doi: 10.1016/j.nbd.2013.08.015. (2013)


Schweizer L, Koelsche C, Sahm F, Piro RM, Capper D, Reuss DE, Pusch S, Habel A, Meyer J, Göck T, Jones DT, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler OD, Pfister SM, von Deimling A.

Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.

Acta Neuropathol. 125(5):651-658 (2013)


Malter MP, Tschampa HJ, Helmstaedter C, Urbach H, von Lehe M, Becker A, Clusmann H, Elger CE, Bien CG

Outcome after epilepsy surgery in patients with MRI features of bilateral ammon's horn sclerosis.

Epilepsy Res. 105(1-2):150-157 (2013)


Bien CG, Tiemeier H, Sassen R, Kuczaty S, Urbach H, von Lehe M, Becker AJ, Bast T, Herkenrath P, Karenfort M, Kruse B, Kurlemann G, Rona S, Schubert-Bast S, Vieker S, Vlaho S, Wilken B, Elger CE.

Rasmussen encephalitis: Incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins.

Epilepsia. 54(3):543-550 (2013)


Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S.

RIM3γ and RIM4γ are key regulators of neuronal arborization.

J Neurosci. 33(2):824-839 (2013)


Pernhorst K, van Loo KM, von Lehe M, Priebe L, Cichon S, Herms S, Hoffmann P, Helmstaedter C, Sander T, Schoch S, Becker AJ.

Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.

Brain Res. 1499:136-144 (2013)


Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F, Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A.

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.

Acta Neuropathol. 125(3):351-358 (2013)


Pernhorst K, Herms S, Hoffmann P, Cichon S, Schulz H, Sander T, Schoch S, Becker AJ, Grote A.

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue.

Seizure. 22(8):675-678 (2013)


Bien CG, Raabe AL, Schramm J, Becker A, Urbach H, Elger CE.

Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009.

Neurol Neurosurg Psychiatry. 84(1):54-61 (2013)


Sahm F, Bissel J, Koelsche C, Schweizer L, Capper D, Reuss D, Böhmer K, Lass U, Göck T, Kalis K, Meyer J, Habel A, Brehmer S, Mittelbronn M, Jones DT, Schittenhelm J, Urbschat S, Ketter R, Heim S, Mawrin C, Hainfellner JA, Berghoff AS, Preusser M, Becker A, Herold-Mende C, Unterberg A, Hartmann C, Kickingereder P, Collins VP, Pfister SM, von Deimling A.

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry.

Acta Neuropathol. 125(5):651-658 (2013)


Koelsche C, Sahm F, Wöhrer A, Jeibmann A, Schittenhelm J, Kohlhof P, Preusser M, Romeike B, Dohmen-Scheufler H, Hartmann C, Mittelbronn M, Becker A, von Deimling A, Capper D.

BRAF mutated Pleomorphic Xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression.

Brain Pathol. 2013 Dec 18 (2013)


Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P.

Albumin storage in neoplastic astroglial elements of gangliogliomas.

Seizure, 22(2):144-150 (2012)


Kaya M, Becker AJ, Gürses C.

Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia.

Epilepsia. ;53 Suppl 6:31-36 (2012)


Berson A, Barbash S, Shaltiel G, Goll Y, Hanin G, Greenberg DS, Ketzef M, Becker AJ, Friedman A, Soreq H.

Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice.

EMBO Mol Med, 4(8):730-742 (2012)


Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P.

Clinico-neuropathological correlations show astroglial albumin storage as common factor in epileptogenic vascular lesions.

Epilepsia, 53(3):539-548 (2012)


Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C.

Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.

J Biol Chem, 287(21):17656-17661 (2012)


Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C.

Dorsal-ventral differences in intrinsic properties in developing CA1 pyramidal cells.

J Neurosci, 32(11):3736-3747 (2012)


Coras R, de Boer OJ, Armstrong D, Becker A, Jacques TS, Miyata H, Thom M, Vinters HV, Spreafico R, Oz B, Marucci G, Pimentel J, Mühlebner A, Zamecnik J, Buccoliero AM, Rogerio F, Streichenberger N, Arai N, Bugiani M, Vogelgesang S, Macaulay R, Salon C, Hans V, Polivka M, Giangaspero F, Fauziah D, Kim JH, Liu L, Dandan W, Gao J, Lindeboom B, Blümcke I, Aronica E.

Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias.

Epilepsia, 53(8):1341-1348 (2012)


Bien CG, Vincent A, Barnett MH, Becker AJ, Blümcke I, Graus F, Jellinger KA, Reuss DE, Ribalta T, Schlegel J, Sutton I, Lassmann H, Bauer J.

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.

. Brain, 135(Pt 5):1622-1638 (2012)


Aronica E, Becker AJ, Spreafico R.

Malformations of cortical development.

Brain Pathology, 22(3):380-401 (2012)


Müller T, Gessi M, Waha A, Isselstein LJ, Luxen D, Freihoff D, Freihoff J, Becker A, Simon M, Hammes J, Denkhaus D, Zur Mühlen A, Pietsch T, Waha A.

Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.

Am J Pathol, 181(2):675-83 (2012)


Gousias K, Becker AJ, Simon M, Niehusmann P.

Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas.

J Neurooncol, 109(3):545-553 (2012)


Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ, Schoch S.

The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus.

J Neurosci, 32(36):12384-12395 (2012)



Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y.

Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo.

J Physiol, 590:5895-5905 (2012)


Ketzef M, Kahn J, Weissberg I, Becker AJ, Friedman A, Gitler D.

Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.

Neuroscience, 189:108-122 (2011)


Zürner M, Mittelstaedt T, tom Dieck S, Becker AJ, Schoch S.

Differential spatiotemporal expression and subcellular localization of Liprin-a proteins indicate isoform specific functions.

J Comp Neurol, 519(15):3019-3039 (2011)


Schönberger A, Gembe E, Grote A, Witt JA, Elger CE, Bien CG, Urbach H, Becker AJ, Niehusmann P.

Genetic analysis of tuberous-sclerosis genes 1 and 2 in non-lesional focal epilepsy.

Epilepsy Behav, 21(3):233-237 (2011)


Wilcke A, Ligges C, Burkhardt J, Alexander M, Wolf C, Quente E, Ahnert P, Hoffmann P, Becker A, Müller-Myhsok B, Cichon S, Boltze J, Kirsten H.

Imaging genetics of FOXP2 in dyslexia.

Eur J Hum Genet, 20(2):224-229 (2011)


Becker SJ, Matusch A, Becker JS, Wu B, Palm C, Becker AJ, Salber D.

Mass Spectrometric Imaging (MSI) of metals for biomedical research.

Int J Mass Spectrom, 307(1-3):3-15 (2011)


Schijns OE, Bien CG, Majores M, von Lehe M, Urbach H, Becker A, Schramm J, Elger CE, Clusmann H.

Presence of temporal gray-white matter abnormalities does not influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis.

Neurosurgery, 68(1):98-106 (2011)


Pernhorst K, Raabe A, Niehusmann P, van Loo KMJ, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ.

Promoter variants determine GABA-homeostasis related gene transcription in human epileptic hippocampi.

J Neuropathol Exp Neurol, 70(12):1080-1088 (2011)


Jung S, Warner LN, Pitsch J, Becker AJ, Poolos NP.

Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus.

J Neurosci, 31(40):14291-14295 (2011)


Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A.

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging.

Proc Natl Acad Sci USA, 108(27):11256-11261 (2011)


Blümcke, I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Özkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R.

The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.

Epilepsia, 52(1):158-174 (2011)


Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB.

The neuronal transporter gene SLC6A15 confers risk to major depression.

Neuron, 70(2):252-265 (2011)


Grote A, Kovacs A, Clusmann H, Becker AJ, Niehusmann P.

Incidental pituicytoma after accidental head trauma - case report and review of literature.

Clin Neuropathol, 29(3):127-33 (2010)


Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A, Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker AJ, De Jonghe P, Lerche H.

Molecular correlates of age-dependent seizures in inherited neonatal-infantile epilepsy.

Brain, 133:1403-1414 (2010)


Niehusmann P, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ.

Presence of human herpes virus-6 DNA in temporal lobe epilepsy brain tissue of patients with history of encephalitis but not other pathologies.

Epilepsia, 51(12):2478-2483 (2010)


Blümcke I, Kistner I, Clusmann H, Schramm J, Becker AJ, Elger C, Bien CG, Merschhemke M, Meencke HJ, Lehmann T, Buchfelder M, Weigel D, Buslei R, Stefan H, Pauli E, Hildebrandt M.

Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies.

Acta Neuropathol, 117(5):535-544 (2009)


Faber-Zuschratter H, Hüttmann K, Steinhäuser C, Becker A, Schramm J, Okafo U, Shanley D, Yilmazer-Hanke DM.

Ultrastructural and functional characterization of satellitosis in the human lateral amygdala associated with Ammon's horn sclerosis.

Acta Neuropathol, 117(5):545-555 (2009)


Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, Dornmair K, Wiendl H.

CD8+ T cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery.

Brain, 132(5):1236-1246 (2009)


Bien CG, Szinay M, Wagner J, Clusmann H, Becker AJ, Urbach H.

Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies.

Arch Neurol, 66(12):1491-1499 (2009)


Mittelsteadt T, Seifert G, Alvárez-Barón E, Steinhäuser C, Becker AJ, Schoch S.

Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain.

J Comp Neurol, 512(4):514-528 (2009)


Snoei J, Urbach H, Engels G, Fassunke J, von Lehe M, Becker AJ, Majores M.

Genetic alterations of protein-o-mannosyltransferase-1 in glioneuronal and glial brain tumors with subarachnoid spread.

Neuropathology. 29(2):116-124 (2009)


Marcelin B, Chauvière L, Becker A, Migliore M, Esclapez M, Bernard C.

h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.

Neurobiol Dis, 33(3):436-447 (2009)


Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A.

Hamartin variants frequent in focal dysplasias and cortical tubers reveal reduced tuberin binding and aberrant subcellular distribution in vitro.

J Neuropathol Exp Neurol, 68(10):1136-1146 (2009)


Schönberger A, Niehusmann P, Urbach H, Majores M, Grote A, Holthausen H, Blümcke I, Deckert M, Becker AJ.

Increased Frequency of Distinct TSC2 Allelic Variants in FCDs with Balloon Cells and Mineralization.

Neuropathology, 5:559-565 (2009)


Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J, Urbach H.

Simple and Complex Dysembryoplastic Neuroepithelial Tumors (DNT): clinical profile, MRI and histopathology.

Neuroradiology, 51(7):433-443 (2009)


ElSharawy A, Hundrieser B, Brosch M, Wittig M, Huse K, Platzer M, Becker AJ, Simon M, Rosenstiel P, Schreiber S, Krawczak M, Hampe J.

Systematic evaluation of the effect of common SNPs on pre-mRNA splicing.

Hum Mutat, 30(4):625-632 (2009)